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Review

The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies

Nadia Sassi12*, Lilia Laadhar2, Maha Driss3, Meriam Kallel-Sellami2, Slaheddine Sellami1 and Sondes Makni2

Author Affiliations

1 Osteoarthritis-osteoporosis Research Laboratory, Rheumatology Department, LaRabta Hospital, 1007 Tunis, Tunisia

2 Immunology Department, LaRabta Hospital, 1007 Tunis, Tunisia

3 Anatomo-pathology Department, Salah Azaiez Health Institute, 1007 Tunis, Tunisia

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Arthritis Research & Therapy 2011, 13:208  doi:10.1186/ar3255

Published: 18 March 2011

Abstract

Osteoarthritis is the most prevalent form of arthritis in the world. With the progressive ageing of the population, it is becoming a major public health problem. The involvement of certain signaling pathways, such as the Notch pathway, during cartilage pathology has been reported. In this review, we report on studies that investigated the expression pattern of the Notch family members in articular cartilage and the eventual involvement of this pathway in the modulation of the physiology and pathology of chondrocytes. Temporal and/or spatial modulation of this signaling pathway may help these cells to synthesize a new functional extracellular matrix and restore the functional properties of the articular cartilage.