Chemerin/ChemR23 pathway: a system beyond chemokines
DiMIMP-Rheumatology Unit, School of Medicine, University of Bari, 70124 Bari, Italy
Arthritis Research & Therapy 2011, 13:104 doi:10.1186/ar3273
See related research by Berg et al., http://arthritis-research.com/content/12/6/R228Published: 6 April 2011
Chemerin is a chemokine that, through the engagement of its counter-receptor, ChemR23, attracts pro-inflammatory cells. However, chemerin has been shown to play other functions and a recent study by Berg and colleagues demonstrates that chemerin/ChemR23 is a system beyond chemokines. Human articular chondrocytes produce chemerin and express ChemR23, and upon stimulation with recombinant chemerin increase the production of pro-catabolic cytokines and metalloproteinases. The latter are up-regulated in osteoarthritic cartilage and cause extracellular matrix breakdown. Since an increase of chemerin in fat tissue and serum of obese patients has been reported, this new feature of chemerin may represent a functional link between obesity and osteoarthritis.