Arthritis Research & Therapy | Volume 13 Issue 2

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Articles

	Volume 13 Issue 2
	Comment
	Editorial Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium Shahla Abdollahi-Roodsaz, Fons AJ van de Loo, Wim B van den Berg Arthritis Research & Therapy 2011, 13:105 (30 March 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Chemerin/ChemR23 pathway: a system beyond chemokines Florenzo Iannone, Giovanni Lapadula Arthritis Research & Therapy 2011, 13:104 (6 April 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Knee osteoarthritis, lumbar-disc degeneration and developmental dysplasia of the hip - an emerging genetic overlap John Loughlin Arthritis Research & Therapy 2011, 13:108 (19 April 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Can ultrasonography make identification of asymptomatic hyperuricemic individuals at risk for developing gouty arthritis more crystal clear? Naomi Schlesinger Arthritis Research & Therapy 2011, 13:107 (19 April 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg? David S Pisetsky Arthritis Research & Therapy 2011, 13:109 (21 April 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial What do measurements of molecular biomarkers in different body fluids really tell us? A Robin Poole Arthritis Research & Therapy 2011, 13:110 (27 April 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Soluble IL-18 receptor complex: a new star in the firmament of rheumatoid arthritis diagnosis? Fons AJ van de Loo Arthritis Research & Therapy 2011, 13:111 (27 April 2011) Abstract \| Full text \| PDF \| PubMed
	Commentary Diversity and flexibility of Th17 effector functions Thomas Kamradt, Hyun-Dong Chang Arthritis Research & Therapy 2011, 13:106 (18 April 2011) Abstract \| Full text \| PDF \| PubMed
	Review
	Review Abnormalities of T cell signaling in systemic lupus erythematosus Vaishali R Moulton, George C Tsokos Arthritis Research & Therapy 2011, 13:207 (17 March 2011) Abstract \| Full text \| PDF \| PubMed
	Review Novel autoantibodies and clinical phenotypes in adult and juvenile myositis Zoe E Betteridge, Harsha Gunawardena, Neil J McHugh Arthritis Research & Therapy 2011, 13:209 (18 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies Nadia Sassi, Lilia Laadhar, Maha Driss, Meriam Kallel-Sellami, Slaheddine Sellami, Sondes Makni Arthritis Research & Therapy 2011, 13:208 (18 March 2011) Abstract \| Full text \| PDF \| PubMed
	Review Osteoarthritis subpopulations and implications for clinical trial design Sita MA Bierma-Zeinstra, Arianne P Verhagen Arthritis Research & Therapy 2011, 13:213 (5 April 2011) Abstract \| Full text \| PDF \| PubMed
	Review Is Sjögren's syndrome a retroviral disease? Nikolaos V Sipsas, Maria N Gamaletsou, Haralampos M Moutsopoulos Arthritis Research & Therapy 2011, 13:212 (13 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Chromatin as a target antigen in human and murine lupus nephritis Annica Hedberg, Elin S Mortensen, Ole P Rekvig Arthritis Research & Therapy 2011, 13:214 (18 April 2011) Abstract \| Full text \| PDF \| PubMed
	Review The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia Yvonne C Lee, Nicholas J Nassikas, Daniel J Clauw Arthritis Research & Therapy 2011, 13:211 (28 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines Hans-Georg Schaible, Andrea Ebersberger, Gabriel Natura Arthritis Research & Therapy 2011, 13:210 (28 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Biochemical markers of ongoing joint damage in rheumatoid arthritis - current and future applications, limitations and opportunities Morten A Karsdal, Thasia Woodworth, Kim Henriksen, Walter P Maksymowych, Harry Genant, Philippe Vergnaud, Claus Christiansen, Tanja Schubert, Per Qvist, Georg Schett, Adam Platt, Anne-Christine Bay-Jensen Arthritis Research & Therapy 2011, 13:215 (28 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Report
	Correction Correction: Steady-state mycophenolate mofetil pharmacokinetic parameters enable prediction of systemic lupus erythematosus clinical flares: an observational cohort study Sarah Djabarouti, Dominique Breilh, Pierre Duffau, Estibaliz Lazaro, Carine Greib, Olivier Caubet, Marie-Claude Saux, Jean-Luc Pellegrin, Jean-François Viallard Arthritis Research & Therapy 2011, 13:401 (3 March 2011) Full text \| PDF \| PubMed
	Correction Correction: mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis Matthew R McCann, Roxana Monemdjou, Parisa Ghassemi-Kakroodi, Hassan Fahmi, Gemma Perez, Shangxi Liu, Xu Shi-wen, Sunil K Parapuram, Fumiaki Kojima, Christopher P Denton, David J Abraham, Johanne Martel-Pelletier, Leslie J Crofford, Andrew Leask, Mohit Kapoor Arthritis Research & Therapy 2011, 13:402 (24 March 2011) Full text \| PDF \| PubMed
	Research
	Research article Treatment of active lupus nephritis with the novel immunosuppressant 15-deoxyspergualin: an open-label dose escalation study Hanns-Martin Lorenz, Wilhelm H Schmitt, Vladimir Tesar, Ulf Müller-Ladner, Ingo Tarner, Ingeborg A Hauser, Falk Hiepe, Tobias Alexander, Heike Woehling, Kyuichi Nemoto, Peter A Heinzel Arthritis Research & Therapy 2011, 13:R36 (1 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary 15-deoxyspergualin decreased proteinurea in patients with lupus nephritis and appears to be reasonably safe with tolerable side effects, with further optimisation of the dosing regimen needed.
	Research article Whole blood lead levels are associated with radiographic and symptomatic knee osteoarthritis: a cross-sectional analysis in the Johnston County Osteoarthritis Project Amanda E Nelson, Xiaoyan A Shi, Todd A Schwartz, Jiu-Chiuan Chen, Jordan B Renner, Kathleen L Caldwell, Charles G Helmick, Joanne M Jordan Arthritis Research & Therapy 2011, 13:R37 (1 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Levels of lead in the blood are associated with the presence and severity of knee osteoarthritis, with further studies necessary to clarify whether lead has a direct toxic effect on joint tissues.
	Research article Risk factors for ANA positivity in healthy persons Quan-Zhen Li, David R Karp, Jiexia Quan, Valerie K Branch, Jinchun Zhou, Yun Lian, Benjamin F Chong, Edward K Wakeland, Nancy J Olsen Arthritis Research & Therapy 2011, 13:R38 (2 March 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Contemporary epidemiology of gout in the UK general population Lucía Cea Soriano, Dietrich Rothenbacher, Hyon K Choi, Luis A García Rodríguez Arthritis Research & Therapy 2011, 13:R39 (3 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Contemporary incidence of gout remains substantial in the UK, with gout-specific treatment patterns remaining relatively unchanged in recent years except for an increase in the use of colchicine.
	Research article The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis Anna-Karin H Ekwall, Thomas Eisler, Christian Anderberg, Chunsheng Jin, Niclas Karlsson, Mikael Brisslert, Maria I Bokarewa Arthritis Research & Therapy 2011, 13:R40 (7 March 2011) Abstract \| Full text \| PDF \| PubMed \| F1000
	Research article TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study Aya Kawasaki, Hiroshi Furukawa, Yuya Kondo, Satoshi Ito, Taichi Hayashi, Makio Kusaoi, Isao Matsumoto, Shigeto Tohma, Yoshinari Takasaki, Hiroshi Hashimoto, Takayuki Sumida, Naoyuki Tsuchiya Arthritis Research & Therapy 2011, 13:R41 (11 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Comparative efficacy of a secretory phospholipase A₂inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis Liam G Coulthard, Jaclyn Costello, Brent Robinson, Ian A Shiels, Stephen M Taylor, Trent M Woodruff Arthritis Research & Therapy 2011, 13:R42 (14 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A direct comparison of a secretory phospholipase A2 inhibitor to conventional anti-arthritic therapies in a rat model of arthritis suggests sPLA2 inhibition may be a safer and more effective alternative.
	Research article Macrophage migration inhibitory factor enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthritis Hae-Rim Kim, Kyoung-Woon Kim, Hong Geun Jung, Kwang-Sup Yoon, Hye-Jwa Oh, Mi-La Cho, Sang-Heon Lee Arthritis Research & Therapy 2011, 13:R43 (14 March 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine Nina Ivanovska, Petya Dimitrova Arthritis Research & Therapy 2011, 13:R44 (16 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis Kristina Juneblad, Martin Johansson, Solbritt Rantapää-Dahlqvist, Gerd-Marie Alenius Arthritis Research & Therapy 2011, 13:R45 (16 March 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis Anna Plaas, Jun Li, Julie Riesco, Rosalina Das, John D Sandy, Andrew Harrison Arthritis Research & Therapy 2011, 13:R46 (20 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells Toshio Kawamoto, Yoshiyuki Abe, Jun Ito, Fumihiko Makino, Yuko Kojima, Yoshihiko Usui, Juan Ma, Shinji Morimoto, Hideo Yagita, Ko Okumura, Yoshinari Takasaki, Hisaya Akiba Arthritis Research & Therapy 2011, 13:R47 (22 March 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Reproduction of overall spontaneous pain pattern by manual stimulation of active myofascial trigger points in fibromyalgia patients Hong-You Ge, Ying Wang, César Fernández-de-las-Peñas, Thomas Graven-Nielsen, Bente Danneskiold-Samsøe, Lars Arendt-Nielsen Arthritis Research & Therapy 2011, 13:R48 (22 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Overall spontaneous fibromyalgia pain pattern can be reproduced by manual stimulation of active myofascial trigger points (MTPs), suggesting active MTPs should be targeted in pain control.
	Research article Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease Eun Ha Kang, Jeong Yeon Kim, Fujio Takeuchi, Joon Wan Kim, Kichul Shin, Eun Young Lee, Yun Jong Lee, Eun Bong Lee, Myoung Hee Park, Yeong Wook Song Arthritis Research & Therapy 2011, 13:R49 (24 March 2011) Abstract \| Full text \| PDF \| PubMed
	Research article The role of synovial fluid markers of catabolism and anabolism in osteoarthritis, rheumatoid arthritis and asymptomatic organ donors Rediet Kokebie, Rohit Aggarwal, Sukhwinderjit Lidder, Arnavaz A Hakimiyan, David C Rueger, Joel A Block, Susan Chubinskaya Arthritis Research & Therapy 2011, 13:R50 (24 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis Anak ASSK Dharmapatni, Malcolm D Smith, Tania N Crotti, Christopher A Holding, Cristina Vincent, Helen M Weedon, Andrew CW Zannettino, Timothy S Zheng, David M Findlay, Gerald J Atkins, David R Haynes Arthritis Research & Therapy 2011, 13:R51 (24 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis Satoko Takei, Tomoaki Hoshino, Kazuko Matsunaga, Yuki Sakazaki, Masanori Sawada, Hanako Oda, Shin-ichi Takenaka, Haruki Imaoka, Takashi Kinoshita, Seiyo Honda, Hiroaki Ida, Taka-aki Fukuda, Hisamichi Aizawa Arthritis Research & Therapy 2011, 13:R52 (24 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum levels of soluble interleukin 18 receptor complex are substantially higher in patients with rheumatoid arthritis and adult-onset Still’s disease compared to controls and may be of diagnostic value.
	Research article Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results of a randomized, dose-ranging study Naomi Schlesinger, Marc De Meulemeester, Andrey Pikhlak, A Eftal Yücel, Dominik Richard, Valda Murphy, Udayasankar Arulmani, Peter Sallstig, Alexander So Arthritis Research & Therapy 2011, 13:R53 (25 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development Alexandra Bäcklund, Meirav Holmdahl, Ragnar Mattsson, Katarina Håkansson, Veronica Lindström, Kutty Nandakumar, Anders Grubb, Rikard Holmdahl Arthritis Research & Therapy 2011, 13:R54 (28 March 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Regulation of chondrocyte gene expression by osteogenic protein-1 Susan Chubinskaya, Lori Otten, Stephan Soeder, Jeffrey A Borgia, Thomas Aigner, David C Rueger, Richard F Loeser Arthritis Research & Therapy 2011, 13:R55 (29 March 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate Yingjuan Lu, Torian W Stinnette, Elaine Westrick, Patrick J Klein, Mark A Gehrke, Vicky A Cross, Iontcho R Vlahov, Philip S Low, Christopher P Leamon Arthritis Research & Therapy 2011, 13:R56 (4 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects Fernando M Pimentel-Santos, Dário Ligeiro, Mafalda Matos, Ana F Mourão, José Costa, Helena Santos, Anabela Barcelos, Fátima Godinho, Patricia Pinto, Margarida Cruz, João E Fonseca, Henrique Guedes-Pinto, Jaime C Branco, Matthew A Brown, Gethin P Thomas Arthritis Research & Therapy 2011, 13:R57 (7 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Distinguishing fibromyalgia from rheumatoid arthritis and systemic lupus in clinical questionnaires: an analysis of the revised Fibromyalgia Impact Questionnaire (FIQR) and its variant, the Symptom Impact Questionnaire (SIQR), along with pain locations Ronald Friend, Robert M Bennett Arthritis Research & Therapy 2011, 13:R58 (8 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A combination of 2 questions from the symptom impact questionnaire plus pain in four locations identified the correct diagnosis in 97% of subjects with fibromyalgia, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
	Research article A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity Yang Feng, Jiayin Shen, Emily D Streaker, Michael Lockwood, Zhongyu Zhu, Philip S Low, Dimiter S Dimitrov Arthritis Research & Therapy 2011, 13:R59 (8 April 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Protein synthesis of the pro-inflammatory S100A8/A9 complex in plasmacytoid dendritic cells and cell surface S100A8/A9 on leukocyte subpopulations in systemic lupus erythematosus Christian Lood, Martin Stenström, Helena Tydén, Birgitta Gullstrand, Eva Källberg, Tomas Leanderson, Lennart Truedsson, Gunnar Sturfelt, Fredrik Ivars, Anders A Bengtsson Arthritis Research & Therapy 2011, 13:R60 (14 April 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Platelet-derived growth factor receptor-β and epidermal growth factor receptor in pulmonary vasculature of systemic sclerosis-associated pulmonary arterial hypertension versus idiopathic pulmonary arterial hypertension and pulmonary veno-occlusive disease: a case-control study Maria J Overbeek, Anco Boonstra, Alexandre E Voskuyl, Madelon C Vonk, Anton Vonk-Noordegraaf, Maria PA van Berkel, Wolter J Mooi, Ben AC Dijkmans, Laurens S Hondema, Egbert F Smit, Katrien Grünberg Arthritis Research & Therapy 2011, 13:R61 (14 April 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis Jun Wu, Carl Ekman, Andreas Jönsen, Gunnar Sturfelt, Anders A Bengtsson, Anders Gottsäter, Bengt Lindblad, Elisabet Lindqvist, Tore Saxne, Björn Dahlbäck Arthritis Research & Therapy 2011, 13:R62 (15 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus Hooi-Ming Lee, Hidehiko Sugino, Chieko Aoki, Norihiro Nishimoto Arthritis Research & Therapy 2011, 13:R63 (15 April 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage David Pretzel, Stefanie Linss, Steffen Rochler, Michaela Endres, Christian Kaps, Saifeddin Alsalameh, Raimund W Kinne Arthritis Research & Therapy 2011, 13:R64 (15 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers Saedis Saevarsdottir, Bo Ding, Kristjan Steinsson, Gerdur Grondal, Helgi Valdimarsson, Lars Alfredsson, Lars Klareskog, Leonid Padyukov Arthritis Research & Therapy 2011, 13:R65 (15 April 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Hyperuricemia and the risk for subclinical coronary atherosclerosis - data from a prospective observational cohort study Eswar Krishnan, Bhavik J Pandya, Lorinda Chung, Omar Dabbous Arthritis Research & Therapy 2011, 13:R66 (18 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Decrease in the incidence of total hip arthroplasties in patients with rheumatoid arthritis - results from a well defined population in south Sweden Korosh Hekmat, Lennart Jacobsson, Jan-Åke Nilsson, Ingemar F Petersson, Otto Robertsson, Göran Garellick, Carl Turesson Arthritis Research & Therapy 2011, 13:R67 (21 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The incidence of hip arthroplasties decreased significantly after 2001 in a cohort in south Sweden, potentially due to the positive effect on joint damage from more aggressive pharmacological treatment.
	Research article A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis Kristine L Stump, Lily D Lu, Pawel Dobrzanski, Cynthia Serdikoff, Diane E Gingrich, Ben J Dugan, Thelma S Angeles, Mark S Albom, Mark A Ator, Bruce D Dorsey, Bruce A Ruggeri, Matthew M Seavey Arthritis Research & Therapy 2011, 13:R68 (21 April 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases Terrance P O'Hanlon, Lisa G Rider, Lu Gan, Rick Fannin, Richard S Paules, David M Umbach, Clarice R Weinberg, Ruchir R Shah, Deepak Mav, Mark F Gourley, Frederick W Miller Arthritis Research & Therapy 2011, 13:R69 (26 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Correspondence
	Letter Response to 'Effect of etanercept in polymyalgia rheumatica: a randomized controlled trial' Pippa Watson, Hill Gaston Arthritis Research & Therapy 2011, 13:403 (6 April 2011) Abstract \| Full text \| PDF \| PubMed
	Letter Response to 'Infliximab therapy increases body fat mass in early rheumatoid arthritis independently of changes in disease activity and levels of leptin and adiponectin: a randomized study over 21 months' Miguel A Gonzalez-Gay, Carlos Gonzalez-Juanatey, Jose A Miranda-Filloy, Javier Martin, Maria T Garcia-Unzueta, Javier Llorca Arthritis Research & Therapy 2011, 13:404 (27 April 2011) Abstract \| Full text \| PDF \| PubMed

	Volume 13 Issue 2
	Comment
	Editorial Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium Shahla Abdollahi-Roodsaz, Fons AJ van de Loo, Wim B van den Berg Arthritis Research & Therapy 2011, 13:105 (30 March 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Chemerin/ChemR23 pathway: a system beyond chemokines Florenzo Iannone, Giovanni Lapadula Arthritis Research & Therapy 2011, 13:104 (6 April 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Knee osteoarthritis, lumbar-disc degeneration and developmental dysplasia of the hip - an emerging genetic overlap John Loughlin Arthritis Research & Therapy 2011, 13:108 (19 April 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Can ultrasonography make identification of asymptomatic hyperuricemic individuals at risk for developing gouty arthritis more crystal clear? Naomi Schlesinger Arthritis Research & Therapy 2011, 13:107 (19 April 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg? David S Pisetsky Arthritis Research & Therapy 2011, 13:109 (21 April 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial What do measurements of molecular biomarkers in different body fluids really tell us? A Robin Poole Arthritis Research & Therapy 2011, 13:110 (27 April 2011) Abstract \| Full text \| PDF \| PubMed
	Editorial Soluble IL-18 receptor complex: a new star in the firmament of rheumatoid arthritis diagnosis? Fons AJ van de Loo Arthritis Research & Therapy 2011, 13:111 (27 April 2011) Abstract \| Full text \| PDF \| PubMed
	Commentary Diversity and flexibility of Th17 effector functions Thomas Kamradt, Hyun-Dong Chang Arthritis Research & Therapy 2011, 13:106 (18 April 2011) Abstract \| Full text \| PDF \| PubMed
	Review
	Review Abnormalities of T cell signaling in systemic lupus erythematosus Vaishali R Moulton, George C Tsokos Arthritis Research & Therapy 2011, 13:207 (17 March 2011) Abstract \| Full text \| PDF \| PubMed
	Review Novel autoantibodies and clinical phenotypes in adult and juvenile myositis Zoe E Betteridge, Harsha Gunawardena, Neil J McHugh Arthritis Research & Therapy 2011, 13:209 (18 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies Nadia Sassi, Lilia Laadhar, Maha Driss, Meriam Kallel-Sellami, Slaheddine Sellami, Sondes Makni Arthritis Research & Therapy 2011, 13:208 (18 March 2011) Abstract \| Full text \| PDF \| PubMed
	Review Osteoarthritis subpopulations and implications for clinical trial design Sita MA Bierma-Zeinstra, Arianne P Verhagen Arthritis Research & Therapy 2011, 13:213 (5 April 2011) Abstract \| Full text \| PDF \| PubMed
	Review Is Sjögren's syndrome a retroviral disease? Nikolaos V Sipsas, Maria N Gamaletsou, Haralampos M Moutsopoulos Arthritis Research & Therapy 2011, 13:212 (13 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Chromatin as a target antigen in human and murine lupus nephritis Annica Hedberg, Elin S Mortensen, Ole P Rekvig Arthritis Research & Therapy 2011, 13:214 (18 April 2011) Abstract \| Full text \| PDF \| PubMed
	Review The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia Yvonne C Lee, Nicholas J Nassikas, Daniel J Clauw Arthritis Research & Therapy 2011, 13:211 (28 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines Hans-Georg Schaible, Andrea Ebersberger, Gabriel Natura Arthritis Research & Therapy 2011, 13:210 (28 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review Biochemical markers of ongoing joint damage in rheumatoid arthritis - current and future applications, limitations and opportunities Morten A Karsdal, Thasia Woodworth, Kim Henriksen, Walter P Maksymowych, Harry Genant, Philippe Vergnaud, Claus Christiansen, Tanja Schubert, Per Qvist, Georg Schett, Adam Platt, Anne-Christine Bay-Jensen Arthritis Research & Therapy 2011, 13:215 (28 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Report
	Correction Correction: Steady-state mycophenolate mofetil pharmacokinetic parameters enable prediction of systemic lupus erythematosus clinical flares: an observational cohort study Sarah Djabarouti, Dominique Breilh, Pierre Duffau, Estibaliz Lazaro, Carine Greib, Olivier Caubet, Marie-Claude Saux, Jean-Luc Pellegrin, Jean-François Viallard Arthritis Research & Therapy 2011, 13:401 (3 March 2011) Full text \| PDF \| PubMed
	Correction Correction: mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis Matthew R McCann, Roxana Monemdjou, Parisa Ghassemi-Kakroodi, Hassan Fahmi, Gemma Perez, Shangxi Liu, Xu Shi-wen, Sunil K Parapuram, Fumiaki Kojima, Christopher P Denton, David J Abraham, Johanne Martel-Pelletier, Leslie J Crofford, Andrew Leask, Mohit Kapoor Arthritis Research & Therapy 2011, 13:402 (24 March 2011) Full text \| PDF \| PubMed
	Research
	Research article Treatment of active lupus nephritis with the novel immunosuppressant 15-deoxyspergualin: an open-label dose escalation study Hanns-Martin Lorenz, Wilhelm H Schmitt, Vladimir Tesar, Ulf Müller-Ladner, Ingo Tarner, Ingeborg A Hauser, Falk Hiepe, Tobias Alexander, Heike Woehling, Kyuichi Nemoto, Peter A Heinzel Arthritis Research & Therapy 2011, 13:R36 (1 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary 15-deoxyspergualin decreased proteinurea in patients with lupus nephritis and appears to be reasonably safe with tolerable side effects, with further optimisation of the dosing regimen needed.
	Research article Whole blood lead levels are associated with radiographic and symptomatic knee osteoarthritis: a cross-sectional analysis in the Johnston County Osteoarthritis Project Amanda E Nelson, Xiaoyan A Shi, Todd A Schwartz, Jiu-Chiuan Chen, Jordan B Renner, Kathleen L Caldwell, Charles G Helmick, Joanne M Jordan Arthritis Research & Therapy 2011, 13:R37 (1 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Levels of lead in the blood are associated with the presence and severity of knee osteoarthritis, with further studies necessary to clarify whether lead has a direct toxic effect on joint tissues.
	Research article Risk factors for ANA positivity in healthy persons Quan-Zhen Li, David R Karp, Jiexia Quan, Valerie K Branch, Jinchun Zhou, Yun Lian, Benjamin F Chong, Edward K Wakeland, Nancy J Olsen Arthritis Research & Therapy 2011, 13:R38 (2 March 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Contemporary epidemiology of gout in the UK general population Lucía Cea Soriano, Dietrich Rothenbacher, Hyon K Choi, Luis A García Rodríguez Arthritis Research & Therapy 2011, 13:R39 (3 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Contemporary incidence of gout remains substantial in the UK, with gout-specific treatment patterns remaining relatively unchanged in recent years except for an increase in the use of colchicine.
	Research article The tumour-associated glycoprotein podoplanin is expressed in fibroblast-like synoviocytes of the hyperplastic synovial lining layer in rheumatoid arthritis Anna-Karin H Ekwall, Thomas Eisler, Christian Anderberg, Chunsheng Jin, Niclas Karlsson, Mikael Brisslert, Maria I Bokarewa Arthritis Research & Therapy 2011, 13:R40 (7 March 2011) Abstract \| Full text \| PDF \| PubMed \| F1000
	Research article TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study Aya Kawasaki, Hiroshi Furukawa, Yuya Kondo, Satoshi Ito, Taichi Hayashi, Makio Kusaoi, Isao Matsumoto, Shigeto Tohma, Yoshinari Takasaki, Hiroshi Hashimoto, Takayuki Sumida, Naoyuki Tsuchiya Arthritis Research & Therapy 2011, 13:R41 (11 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Comparative efficacy of a secretory phospholipase A₂inhibitor with conventional anti-inflammatory agents in a rat model of antigen-induced arthritis Liam G Coulthard, Jaclyn Costello, Brent Robinson, Ian A Shiels, Stephen M Taylor, Trent M Woodruff Arthritis Research & Therapy 2011, 13:R42 (14 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A direct comparison of a secretory phospholipase A2 inhibitor to conventional anti-arthritic therapies in a rat model of arthritis suggests sPLA2 inhibition may be a safer and more effective alternative.
	Research article Macrophage migration inhibitory factor enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthritis Hae-Rim Kim, Kyoung-Woon Kim, Hong Geun Jung, Kwang-Sup Yoon, Hye-Jwa Oh, Mi-La Cho, Sang-Heon Lee Arthritis Research & Therapy 2011, 13:R43 (14 March 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine Nina Ivanovska, Petya Dimitrova Arthritis Research & Therapy 2011, 13:R44 (16 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Association between the PTPN22 +1858 C/T polymorphism and psoriatic arthritis Kristina Juneblad, Martin Johansson, Solbritt Rantapää-Dahlqvist, Gerd-Marie Alenius Arthritis Research & Therapy 2011, 13:R45 (16 March 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis Anna Plaas, Jun Li, Julie Riesco, Rosalina Das, John D Sandy, Andrew Harrison Arthritis Research & Therapy 2011, 13:R46 (20 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Anti-T cell immunoglobulin and mucin domain-2 monoclonal antibody exacerbates collagen-induced arthritis by stimulating B cells Toshio Kawamoto, Yoshiyuki Abe, Jun Ito, Fumihiko Makino, Yuko Kojima, Yoshihiko Usui, Juan Ma, Shinji Morimoto, Hideo Yagita, Ko Okumura, Yoshinari Takasaki, Hisaya Akiba Arthritis Research & Therapy 2011, 13:R47 (22 March 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Reproduction of overall spontaneous pain pattern by manual stimulation of active myofascial trigger points in fibromyalgia patients Hong-You Ge, Ying Wang, César Fernández-de-las-Peñas, Thomas Graven-Nielsen, Bente Danneskiold-Samsøe, Lars Arendt-Nielsen Arthritis Research & Therapy 2011, 13:R48 (22 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Overall spontaneous fibromyalgia pain pattern can be reproduced by manual stimulation of active myofascial trigger points (MTPs), suggesting active MTPs should be targeted in pain control.
	Research article Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease Eun Ha Kang, Jeong Yeon Kim, Fujio Takeuchi, Joon Wan Kim, Kichul Shin, Eun Young Lee, Yun Jong Lee, Eun Bong Lee, Myoung Hee Park, Yeong Wook Song Arthritis Research & Therapy 2011, 13:R49 (24 March 2011) Abstract \| Full text \| PDF \| PubMed
	Research article The role of synovial fluid markers of catabolism and anabolism in osteoarthritis, rheumatoid arthritis and asymptomatic organ donors Rediet Kokebie, Rohit Aggarwal, Sukhwinderjit Lidder, Arnavaz A Hakimiyan, David C Rueger, Joel A Block, Susan Chubinskaya Arthritis Research & Therapy 2011, 13:R50 (24 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article TWEAK and Fn14 expression in the pathogenesis of joint inflammation and bone erosion in rheumatoid arthritis Anak ASSK Dharmapatni, Malcolm D Smith, Tania N Crotti, Christopher A Holding, Cristina Vincent, Helen M Weedon, Andrew CW Zannettino, Timothy S Zheng, David M Findlay, Gerald J Atkins, David R Haynes Arthritis Research & Therapy 2011, 13:R51 (24 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis Satoko Takei, Tomoaki Hoshino, Kazuko Matsunaga, Yuki Sakazaki, Masanori Sawada, Hanako Oda, Shin-ichi Takenaka, Haruki Imaoka, Takashi Kinoshita, Seiyo Honda, Hiroaki Ida, Taka-aki Fukuda, Hisamichi Aizawa Arthritis Research & Therapy 2011, 13:R52 (24 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Serum levels of soluble interleukin 18 receptor complex are substantially higher in patients with rheumatoid arthritis and adult-onset Still’s disease compared to controls and may be of diagnostic value.
	Research article Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results of a randomized, dose-ranging study Naomi Schlesinger, Marc De Meulemeester, Andrey Pikhlak, A Eftal Yücel, Dominik Richard, Valda Murphy, Udayasankar Arulmani, Peter Sallstig, Alexander So Arthritis Research & Therapy 2011, 13:R53 (25 March 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development Alexandra Bäcklund, Meirav Holmdahl, Ragnar Mattsson, Katarina Håkansson, Veronica Lindström, Kutty Nandakumar, Anders Grubb, Rikard Holmdahl Arthritis Research & Therapy 2011, 13:R54 (28 March 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Regulation of chondrocyte gene expression by osteogenic protein-1 Susan Chubinskaya, Lori Otten, Stephan Soeder, Jeffrey A Borgia, Thomas Aigner, David C Rueger, Richard F Loeser Arthritis Research & Therapy 2011, 13:R55 (29 March 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate Yingjuan Lu, Torian W Stinnette, Elaine Westrick, Patrick J Klein, Mark A Gehrke, Vicky A Cross, Iontcho R Vlahov, Philip S Low, Christopher P Leamon Arthritis Research & Therapy 2011, 13:R56 (4 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Whole blood transcriptional profiling in ankylosing spondylitis identifies novel candidate genes that might contribute to the inflammatory and tissue-destructive disease aspects Fernando M Pimentel-Santos, Dário Ligeiro, Mafalda Matos, Ana F Mourão, José Costa, Helena Santos, Anabela Barcelos, Fátima Godinho, Patricia Pinto, Margarida Cruz, João E Fonseca, Henrique Guedes-Pinto, Jaime C Branco, Matthew A Brown, Gethin P Thomas Arthritis Research & Therapy 2011, 13:R57 (7 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Distinguishing fibromyalgia from rheumatoid arthritis and systemic lupus in clinical questionnaires: an analysis of the revised Fibromyalgia Impact Questionnaire (FIQR) and its variant, the Symptom Impact Questionnaire (SIQR), along with pain locations Ronald Friend, Robert M Bennett Arthritis Research & Therapy 2011, 13:R58 (8 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A combination of 2 questions from the symptom impact questionnaire plus pain in four locations identified the correct diagnosis in 97% of subjects with fibromyalgia, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
	Research article A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity Yang Feng, Jiayin Shen, Emily D Streaker, Michael Lockwood, Zhongyu Zhu, Philip S Low, Dimiter S Dimitrov Arthritis Research & Therapy 2011, 13:R59 (8 April 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Protein synthesis of the pro-inflammatory S100A8/A9 complex in plasmacytoid dendritic cells and cell surface S100A8/A9 on leukocyte subpopulations in systemic lupus erythematosus Christian Lood, Martin Stenström, Helena Tydén, Birgitta Gullstrand, Eva Källberg, Tomas Leanderson, Lennart Truedsson, Gunnar Sturfelt, Fredrik Ivars, Anders A Bengtsson Arthritis Research & Therapy 2011, 13:R60 (14 April 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Platelet-derived growth factor receptor-β and epidermal growth factor receptor in pulmonary vasculature of systemic sclerosis-associated pulmonary arterial hypertension versus idiopathic pulmonary arterial hypertension and pulmonary veno-occlusive disease: a case-control study Maria J Overbeek, Anco Boonstra, Alexandre E Voskuyl, Madelon C Vonk, Anton Vonk-Noordegraaf, Maria PA van Berkel, Wolter J Mooi, Ben AC Dijkmans, Laurens S Hondema, Egbert F Smit, Katrien Grünberg Arthritis Research & Therapy 2011, 13:R61 (14 April 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis Jun Wu, Carl Ekman, Andreas Jönsen, Gunnar Sturfelt, Anders A Bengtsson, Anders Gottsäter, Bengt Lindblad, Elisabet Lindqvist, Tore Saxne, Björn Dahlbäck Arthritis Research & Therapy 2011, 13:R62 (15 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Underexpression of mitochondrial-DNA encoded ATP synthesis-related genes and DNA repair genes in systemic lupus erythematosus Hooi-Ming Lee, Hidehiko Sugino, Chieko Aoki, Norihiro Nishimoto Arthritis Research & Therapy 2011, 13:R63 (15 April 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage David Pretzel, Stefanie Linss, Steffen Rochler, Michaela Endres, Christian Kaps, Saifeddin Alsalameh, Raimund W Kinne Arthritis Research & Therapy 2011, 13:R64 (15 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers Saedis Saevarsdottir, Bo Ding, Kristjan Steinsson, Gerdur Grondal, Helgi Valdimarsson, Lars Alfredsson, Lars Klareskog, Leonid Padyukov Arthritis Research & Therapy 2011, 13:R65 (15 April 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Hyperuricemia and the risk for subclinical coronary atherosclerosis - data from a prospective observational cohort study Eswar Krishnan, Bhavik J Pandya, Lorinda Chung, Omar Dabbous Arthritis Research & Therapy 2011, 13:R66 (18 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Decrease in the incidence of total hip arthroplasties in patients with rheumatoid arthritis - results from a well defined population in south Sweden Korosh Hekmat, Lennart Jacobsson, Jan-Åke Nilsson, Ingemar F Petersson, Otto Robertsson, Göran Garellick, Carl Turesson Arthritis Research & Therapy 2011, 13:R67 (21 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The incidence of hip arthroplasties decreased significantly after 2001 in a cohort in south Sweden, potentially due to the positive effect on joint damage from more aggressive pharmacological treatment.
	Research article A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis Kristine L Stump, Lily D Lu, Pawel Dobrzanski, Cynthia Serdikoff, Diane E Gingrich, Ben J Dugan, Thelma S Angeles, Mark S Albom, Mark A Ator, Bruce D Dorsey, Bruce A Ruggeri, Matthew M Seavey Arthritis Research & Therapy 2011, 13:R68 (21 April 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases Terrance P O'Hanlon, Lisa G Rider, Lu Gan, Rick Fannin, Richard S Paules, David M Umbach, Clarice R Weinberg, Ruchir R Shah, Deepak Mav, Mark F Gourley, Frederick W Miller Arthritis Research & Therapy 2011, 13:R69 (26 April 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Correspondence
	Letter Response to 'Effect of etanercept in polymyalgia rheumatica: a randomized controlled trial' Pippa Watson, Hill Gaston Arthritis Research & Therapy 2011, 13:403 (6 April 2011) Abstract \| Full text \| PDF \| PubMed
	Letter Response to 'Infliximab therapy increases body fat mass in early rheumatoid arthritis independently of changes in disease activity and levels of leptin and adiponectin: a randomized study over 21 months' Miguel A Gonzalez-Gay, Carlos Gonzalez-Juanatey, Jose A Miranda-Filloy, Javier Martin, Maria T Garcia-Unzueta, Javier Llorca Arthritis Research & Therapy 2011, 13:404 (27 April 2011) Abstract \| Full text \| PDF \| PubMed

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