Table 1 |
|||||||||
|
Prospective studies investigating relationship CV disease and low BMD |
|||||||||
|
Study |
Study population (years follow-up) |
Number of cases (% women) |
Postmenopausal women |
CV disease excluded |
Mean age |
Outcome CV disease |
Outcome bone mass |
Results # |
Quality |
|
|
|||||||||
|
Sennerby, 2009 [13] |
Population-based (20) |
31,936 (NA) |
NA |
Yes |
67.9 to 74.4 |
CV disease by National patient registry, ICD 9 codes |
Incident hip fracture by National patient registry, ICD 9 codes |
Women: HR: 4.42 (95% CI 3.49 to 5.61) Men: HR: 6.65 (95% CI 4.82 to 9.19) |
3 |
|
Szulc, 2008 [14] |
Population-based (10) |
781 (0%) |
No |
No |
65 |
AC by X-spine |
Incident fracture by hospital records or X-ray |
OR: 2.54 to 3.04 (P < 0.005 to 0.001) |
3 |
|
Naves, 2008 [4] |
Population-based (4) |
624 (51%) |
NA |
No |
65 |
AC by X-spine |
BMD lumbar spine and femur by DXA Incident fracture by hospital record or X-ray |
Change BMD spine in progression AC vs no progression AC: -1.48% vs 1.43% (P <.0001) Change BMD hip in progression AC and no progression AC: -0.48% vs 0.23% (P = 0.315) Incident fracture: OR: 2.13 (95% CI 0.85 to 5.31) |
3 |
|
Von Muhlen, 2009 [15] |
Population-based (4) |
1,332 (60%) |
NA |
No |
73.8 |
PAD by ABI |
BMD lumbar spine and hip by DXA and incident fracture by X-ray |
Women: Change BMD in PAD vs no PAD: 59.2% vs 43.5% (P < 0.05) Incident non-vert fracture: OR: 0.84 (95% CI 0.31 to 2.26) Men : Change BMD in PAD vs no PAD : 43.5% vs 35.5% (P = 0.20) Incident non-vert fracture: OR: 1.52 (95% CI 0.30 to 7.45) |
3 |
|
Collins, 2009 [2] |
Population-based (5.4) |
4,302 (0%) |
NA |
No |
73.5 |
PAD by ABI |
BMD hip by DXA Incident fractures by x-ray and hospital records |
Change BMD in PAD vs no PAD: -0.60% vs -0.32% (P < 0.001 PAD and non-vert fracture risk: HR = 1.47 (95% CI 1.07 to 2.04) |
3 |
|
Hak, 2000 [3] |
Population-based (9) |
236 (100%) |
No (100%) |
No |
49 |
AC by X-spine |
MCA by radiogrammetry |
MCA in patients with AC progression vs no AC progression -3.5 mm vs -2.0 mm (P < 0.01) |
3 |
|
Samelson, 2007 [12] |
Population-based (21) |
2,499 (58%) |
No |
61 |
AC by X-spine |
Incident hip fracture by hospital records and death certificates |
Women: HR: 1.4 (0.8 to 2.3) Men: HR: 1.2 (0.2 to 5.7) |
4 |
|
|
Bagger, 2006 [1] |
Population-based (7.5) |
2,262 (100%) |
Yes (100%) |
No |
65 |
AC by X-spine |
BMD lumbar spine and hip and incident fractures by hospital records or X-ray |
Change hip BMD AC score ≥3 vs <3: -0.38% vs -0.25% (P < 0.001) AC and hip fracture: OR: 2.3 (95% CI 1.1 to 4.8) AC and vert fracture: OR: 1.2 (95% CI 1.0 to 1.5) |
4 |
|
Schulz, 2004 [17] |
Clinic-based (8) |
228 (100%) |
Yes |
No |
65.2 |
AC by CT-scan of spine |
BMD spine by CT-scan |
Change BMD AC vs no AC: -5.3% vs -1.3% (P < 0.001) |
6 |
|
|
|||||||||
|
#adjusted for confounders; NA, not available; AC, aortic calcification; BMD, bone mineral density; DXA, dual-energy x-ray absorptiometry; PAD, peripheral arterial disease; ABI, ankle brachial index; MCA, metacarpal cortical area. |
|||||||||
|
den Uyl et al. Arthritis Research & Therapy 2011 13:R5 doi:10.1186/ar3224 |
|||||||||
