Table 4 |
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|
Biomarker levels in each subgroups according to both the radiographic classification and knee pain |
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|
Radiographic OA |
Pain |
Mean |
SE |
95% CI of the mean |
P-value |
95% CI for difference |
||
|
Lower |
Upper |
|||||||
|
|
||||||||
|
sC2C |
K/L 1 |
- |
5.49 |
0.04 |
5.40 |
5.57 |
0.02* |
-0.19 to -0.04 |
|
Ln (pmol/ml) |
+ |
5.75 |
0.07 |
5.61 |
5.91 |
|||
|
K/L 2 |
- |
5.43 |
0.07 |
5.29 |
5.57 |
1.00 |
-0.36 to 0.35 |
|
|
+ |
5.44 |
0.11 |
5.21 |
5.66 |
||||
|
sCPII |
K/L 1 |
- |
7.38 |
0.07 |
7.24 |
7.52 |
0.01* |
-0.83 to -0.10 |
|
Ln (ng/ml) |
+ |
7.84 |
0.11 |
7.62 |
8.07 |
|||
|
K/L 2 |
- |
7.05 |
0.11 |
6.83 |
7.28 |
1.00 |
-0.44 to 0.71 |
|
|
+ |
6.92 |
0.18 |
6.56 |
7.28 |
||||
|
uCTX-II/Cr |
K/L 1 |
- |
5.04 |
0.14 |
4.76 |
5.32 |
0.07 |
-1.48 to 0.03 |
|
Ln (ng/μmol creatinine) |
+ |
5.77 |
0.22 |
5.32 |
6.22 |
|||
|
K/L 2 |
- |
5.38 |
0.23 |
4.92 |
5.83 |
<0.05* |
-2.36 to -0.05 |
|
|
+ |
6.56 |
0.36 |
5.82 |
7.29 |
||||
|
sC2C |
K/L 1 |
- |
0.15 |
0.03 |
0.10 |
0.20 |
1.00 |
-1.12 to 0.17 |
|
/sCPII |
+ |
0.12 |
0.04 |
0.04 |
0.21 |
|||
|
K/L 2 |
- |
0.27 |
0.04 |
0.19 |
0.36 |
1.00 |
-0.17 to 0.26 |
|
|
+ |
0.23 |
0.07 |
0.09 |
0.37 |
||||
|
uCTX-II/sCPII |
K/L 1 |
- |
0.09 |
0.06 |
-0.03 |
0.22 |
1.00 |
-0.39 to 0.29 |
|
+ |
0.14 |
0.10 |
-0.06 |
0.35 |
||||
|
K/L 2 |
- |
0.42 |
0.10 |
0.21 |
0.63 |
<0.05* |
-1.07 to 0 |
|
|
+ |
0.95 |
0.17 |
0.62 |
1.29 |
||||
|
uNTX/Cr |
K/L 1 |
- |
3.71 |
0.11 |
3.48 |
3.93 |
1.00 |
-0.89 to 0.33 |
|
Ln (ng/ml creatinine) |
+ |
3.99 |
0.18 |
3.62 |
4.35 |
|||
|
K/L 2 |
- |
3.33 |
0.18 |
2.96 |
3.70 |
0.73 |
-1.49 to 0.41 |
|
|
+ |
3.87 |
0.29 |
3.27 |
4.47 |
||||
|
sHA |
K/L 1 |
- |
2.77 |
0.13 |
2.51 |
3.03 |
0.06 |
-1.40 to 0.01 |
|
Ln (pmol/ml) |
+ |
3.46 |
0.21 |
3.04 |
3.89 |
|||
|
K/L 2 |
- |
3.66 |
0.21 |
3.24 |
4.09 |
1.00 |
-1.42 to 0.78 |
|
|
+ |
3.98 |
0.34 |
3.29 |
4.67 |
||||
|
|
||||||||
|
All analyses were adjusted for age, sex and body mass index. The urinary biomarkers were corrected for creatinine. *P-values less than or equal to 0.05 are statistically significant. 95% CI, 95% confidence interval; C2C, cartilage collagen type II cleavage; CPII, cartilage type II collagen carboxy propeptide; CTX-II, type II collagen C-telopeptide; HA, hyaluronic acid; K/L, Kellgren-Lawrence grade; Ln, natural log; NTx, N-terminal crosslinking telopeptide of type I collagen; s, serum; SE, standard error of the mean; u, urine. |
||||||||
|
Ishijima et al. Arthritis Research & Therapy 2011 13:R22 doi:10.1186/ar3246 |
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