Bcl-2 expression in infiltrating lymphocytes of pSS patients and non-SS controls. A) Bcl-2 detected in salivary glands of a pSS patient with FS = 1, a pSS patient with FS = 4, in a subject with chronically inflamed glands (CIG) and a subject with normal gland (NG) histology. Bcl-2 was expressed in the cytoplasm of mononuclear cells both in the focal infiltrates of pSS patients and interstitially in all study groups. B) Amount of Bcl-2+ interstitial cells and C) Bcl-2+ cells in the focal infiltrates presented as number of cells per mm2. Grey bars represent FS = 1 (n = 8), black bars represent FS ≥2 (n = 7), striped bars represent chronic inflammation (n = 5) and white bars represent normal gland histology (n = 5). Results presented as mean ± SEM. Statistical analyses determined by Kolmogorov-Smirnov and Student t test (*P < 0.05, **P < 0.005 and ***P < 0.001).
Szyszko et al. Arthritis Research & Therapy 2011 13:R2 doi:10.1186/ar3220