Figure 3.

Metabolic patterns seen in patients and healthy controls. (A) Heat map showing the standard score for the each metabolite for each rheumatoid arthritis (RA) patient and each healthy control. The standard score shows how the concentration of each metabolite is related to the mean value of the control group for each individual. The standard score was calculated using the mean of the controls to attenuate the RA patients. Yellow color indicates that the metabolite is increased compared to the mean of the control group; red that it is decreased. Metabolites are sorted according to the correlation to RA in the RA versus control orthogonal projections to latent structures-discriminant analysis (OPLS-DA) model. The standard score is truncated to -2/2 for clarity. (B) Similar plot to Figure 3A, but showing RA and psoriatic arthritis (PsoA) patients. The standard score was calculated using the mean of the PsoA patients to attenuate the RA patients. Yellow color indicates that the metabolite is increased compared to the mean of the PsoA group; red that it is decreased. Metabolites are sorted according to the correlation to RA in the RA versus PsoA OPLS-DA model. The standard score is truncated to -2/2.