Open Access Research article

A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis

Susan K Wallis, Laura A Cooney, Judith L Endres, Min Jie Lee, Jennifer Ryu, Emily C Somers and David A Fox*

Author Affiliations

Division of Rheumatology and Rheumatic Diseases Research Core Center, Department of Internal Medicine, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA

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Arthritis Research & Therapy 2011, 13:R15  doi:10.1186/ar3239

Published: 4 February 2011

Additional files

Additional file 1:

Table S1, Supplemental Figures S1 and S2. Table S1. Baseline characteristics of study patients. Figure S1. Regulation of interleukin-17 production in vitro. Figure S2. Inhibition of interleukin (IL)-17 production by IL-4: effect of IL-4R genotype in rheumatoid arthritis patients.

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