Table 3

Regression analysis of mannose-binding lectin genotype groups and pregnancy outcome measures based on dichotomous variablesa

MBL genotype groups A, B and C (three strata)

MBL genotype group A vs. B plus C (dichotomous)



Variable stratified

OR

95% CI

n

OR

95% CI

n


Miscarriage

No correction

1.13

0.64 to 1.99

21/205

1.31

0.53 to 3.23

21/205

Correction for all confounders

0.99

0.53 to 1.83

20/178

1.12

0.43 to 2.87

20/178

Hypertension

No correction

0.93

0,53 to 1.66

23/174

0.72

0.30 to 1.78

23/174

Correction for all confounders

0.76

0.36 to 1.61

16/127

0.58

0.18 to 1.83

16/127

Gestational age (<37 wk)

No correction

1.30

0.68 to 2.58

14/157

1.20

0.40 to 3.60

14/157

Correction for all confounders

2.12

0.80 to 5.60

13/127

2.38

0.47 to 12.1

13/127

Low birth weight (<2,500 g)

No correction

0.93

0.40 to 2.28

10/158

0.76

0.21 to 2.82

10/158

Correction for all confounders

0.92

0.30 to 2.90

9/127

0.87

0.14 to 5.38

9/127


aDichotomous variable outcome measures include miscarriage, hypertension, gestational age and low birth weight in patients with rheumatoid arthritis. MBL, mannose-binding lectin; A, B and C, MBL production genotype groups A (high), B (intermediate) and C (low); OR, odds ratio; 95% CI, 95% confidence interval.

van de Geijn et al. Arthritis Research & Therapy 2011 13:R10   doi:10.1186/ar3231

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