Arthritis Research & Therapy | Volume 13 Issue 1

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Articles

	Volume 13 Issue 1
	Comment
	Editorial Molecular targets of natural health products in arthritis Sarah Khalifé, Muhammad Zafarullah Arthritis Research & Therapy 2011, 13:102 (3 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Editorial Nordic walking in fibromyalgia: a means of promoting fitness that is easy for busy clinicians to recommend Kim Jones Arthritis Research & Therapy 2011, 13:103 (16 February 2011) Abstract \| Full text \| PDF \| PubMed
	Commentary Promise and pitfalls of the Immunochip Adrian Cortes, Matthew A Brown Arthritis Research & Therapy 2011, 13:101 (1 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review
	Review A window on disease pathogenesis and potential therapeutic strategies: molecular imaging for arthritis Luke L Gompels, Ewa M Paleolog Arthritis Research & Therapy 2011, 13:201 (31 January 2011) Abstract \| Full text \| PDF \| PubMed
	Review Managing pregnancy in inflammatory rheumatological diseases Varsha Jain, Caroline Gordon Arthritis Research & Therapy 2011, 13:206 (25 February 2011) Abstract \| Full text \| PDF \| PubMed
	Review Disturbances of apoptotic cell clearance in systemic lupus erythematosus Wen-Hai Shao, Philip L Cohen Arthritis Research & Therapy 2011, 13:202 (28 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review The interplay of inflammation and cardiovascular disease in systemic lupus erythematosus J Michelle Kahlenberg, Mariana J Kaplan Arthritis Research & Therapy 2011, 13:203 (28 February 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Kahlenberg and Kaplan describe the interplay of cardiac risk factors and systemic lupus erythematosus (SLE)-specific mechanisms in the development of accelerated atherosclerosis in SLE patients and discuss potential therapeutic targets.
	Review In vivo approaches to investigate ANCA-associated vasculitis: lessons and limitations Peter Heeringa, Mark A Little Arthritis Research & Therapy 2011, 13:204 (28 February 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This review article explores the advantages and limitations of animal models currently used to investigate the unique pathogenic mechanisms involved in anti-neutrophil cytoplasm antibody-associated vasculitis.
	Review What have we learned from clinical trials in primary Sjögren's syndrome about pathogenesis? Cees GM Kallenberg, Arjan Vissink, Frans GM Kroese, Wayel H Abdulahad, Hendrika Bootsma Arthritis Research & Therapy 2011, 13:205 (28 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research
	Research article Validating English- and Spanish-language patient-reported outcome measures in underserved patients with rheumatic disease Gwenyth R Wallen, Kimberly R Middleton, Migdalia V Rivera-Goba, Barbara B Mittleman Arthritis Research & Therapy 2011, 13:R1 (5 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Salivary glands of primary Sjögren's syndrome patients express factors vital for plasma cell survival Ewa A Szyszko, Karl A Brokstad, Gunnvor Øijordsbakken, Malin V Jonsson, Roland Jonsson, Kathrine Skarstein Arthritis Research & Therapy 2011, 13:R2 (7 January 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts Sandeep K Agarwal, Minghua Wu, Christopher K Livingston, Donald H Parks, Maureen D Mayes, Frank C Arnett, Filemon K Tan Arthritis Research & Therapy 2011, 13:R3 (11 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Joint and tendon subclinical involvement suggestive of gouty arthritis in asymptomatic hyperuricemia: an ultrasound controlled study Carlos Pineda, Luis M Amezcua-Guerra, Carla Solano, Pedro Rodriguez-Henríquez, Cristina Hernández-Díaz, Angelica Vargas, Fritz Hofmann, Marwin Gutiérrez Arthritis Research & Therapy 2011, 13:R4 (17 January 2011) Abstract \| Full text \| PDF \| PubMed
	Research article (Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis Debby den Uyl, Mike T Nurmohamed, Lilian HD van Tuyl, Hennie G Raterman, Willem F Lems Arthritis Research & Therapy 2011, 13:R5 (17 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Individuals with subclinical cardiovascular disease are at greater risk of bone loss and subsequent fractures, suggesting the need for bone density screening in patients with this disease.
	Research article mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis Matthew R McCann, Roxana Monemdjou, Parisa Ghassemi-Kakroodi, Hassan Fahmi, Gemma Perez, Shangxi Liu, Xu Shi-wen, Sunil K Parapuram, Fumiaki Kojima, Christopher P Denton, David J Abraham, Johanne Martel-Pelletier, Leslie J Crofford, Andrew Leask, Mohit Kapoor Arthritis Research & Therapy 2011, 13:R6 (25 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy - a single centre, open-label study Eliza K Pontifex, Danielle M Gerlag, Martina Gogarty, Marjolein Vinkenoog, Adrian Gibbs, Ilse Burgman, Ursula Fearon, Barry Bresnihan, Paul Tak, Robin G Gibney, Douglas J Veale, Oliver FitzGerald Arthritis Research & Therapy 2011, 13:R7 (27 January 2011) Abstract \| Full text \| PDF \| PubMed
	Research article The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration Hamish TJ Gilbert, Judith A Hoyland, Anthony J Freemont, Sarah J Millward-Sadler Arthritis Research & Therapy 2011, 13:R8 (28 January 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Anti-class a scavenger receptor autoantibodies from systemic lupus erythematosus patients impair phagocytic clearance of apoptotic cells by macrophages in vitro Xiao-wei Chen, Yan Shen, Chuan-yin Sun, Feng-xia Wu, Yi Chen, Cheng-de Yang Arthritis Research & Therapy 2011, 13:R9 (31 January 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Mannose-binding lectin does not explain the course and outcome of pregnancy in rheumatoid arthritis Fleur E van de Geijn, Yaël A de Man, Manfred Wuhrer, Sten P Willemsen, André M Deelder, Johanna MW Hazes, Radboud JEM Dolhain Arthritis Research & Therapy 2011, 13:R10 (31 January 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population Ling-hong Liao, Hao Zhang, Man-Po Lai, Shun-Le Chen, Madeline Wu, Nan Shen Arthritis Research & Therapy 2011, 13:R11 (31 January 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis Anne Hinks, Paul Martin, Edward Flynn, Steve Eyre, Jon Packham, Childhood Arthritis Prospective Study (CAPS), BSPAR study group, Anne Barton, Jane Worthington, Wendy Thomson Arthritis Research & Therapy 2011, 13:R12 (31 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis Heidi Kokkonen, Mohammed Mullazehi, Ewa Berglin, Göran Hallmans, Göran Wadell, Johan Rönnelid, Solbritt Rantapää-Dahlqvist Arthritis Research & Therapy 2011, 13:R13 (3 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Dual role of interleukin-17 in pannus growth and osteoclastogenesis in rheumatoid arthritis Hiroshi Ito, Hidehiro Yamada, Toshiko N Shibata, Hirofumi Mitomi, So Nomoto, Shoichi Ozaki Arthritis Research & Therapy 2011, 13:R14 (4 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis Susan K Wallis, Laura A Cooney, Judith L Endres, Min Jie Lee, Jennifer Ryu, Emily C Somers, David A Fox Arthritis Research & Therapy 2011, 13:R15 (4 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Bone mineral density and body composition in postmenopausal women with psoriasis and psoriatic arthritis Paulo G Pedreira, Marcelo M Pinheiro, Vera L Szejnfeld Arthritis Research & Therapy 2011, 13:R16 (7 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Follistatin-like protein 1 is elevated in systemic autoimmune diseases and correlated with disease activity in patients with rheumatoid arthritis Dawei Li, Yuji Wang, Nanwei Xu, Qianghua Wei, Min Wu, Xiaofeng Li, Ping Zheng, Sai Sun, Yuli Jin, Gailian Zhang, Ruomin Liao, Ping Zhang Arthritis Research & Therapy 2011, 13:R17 (8 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis Bradley J Rabquer, Pei-Suen Tsou, Yong Hou, Eshwar Thirunavukkarasu, G Kenneth Haines, Ann J Impens, Kristine Phillips, Bashar Kahaleh, James R Seibold, Alisa E Koch Arthritis Research & Therapy 2011, 13:R18 (8 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Diagnostic properties of metabolic perturbations in rheumatoid arthritis Rasmus K Madsen, Torbjörn Lundstedt, Jon Gabrielsson, Carl-Johan Sennbro, Gerd-Marie Alenius, Thomas Moritz, Solbritt Rantapää-Dahlqvist, Johan Trygg Arthritis Research & Therapy 2011, 13:R19 (8 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Diagnostic value and clinical laboratory associations of antibodies against recombinant ribosomal P0, P1 and P2 proteins and their native heterocomplex in a Caucasian cohort with systemic lupus erythematosus Fidan Barkhudarova, Cornelia Dähnrich, Anke Rosemann, Udo Schneider, Winfried Stöcker, Gerd-Rüdiger Burmester, Karl Egerer, Wolfgang Schlumberger, Falk Hiepe, Robert Biesen Arthritis Research & Therapy 2011, 13:R20 (10 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Anti-dsDNA-NcX ELISA: dsDNA-loaded nucleosomes improve diagnosis and monitoring of disease activity in systemic lupus erythematosus Robert Biesen, Cornelia Dähnrich, Anke Rosemann, Fidan Barkhudarova, Thomas Rose, Olga Jakob, Anne Bruns, Marina Backhaus, Winfried Stöcker, Gerd-Rüdiger Burmester, Wolfgang Schlumberger, Karl Egerer, Falk Hiepe Arthritis Research & Therapy 2011, 13:R26 (10 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Expression of K_2P5.1 potassium channels on CD4⁺T lymphocytes correlates with disease activity in rheumatoid arthritis patients Stefan Bittner, Nicole Bobak, Martin Feuchtenberger, Alexander M Herrmann, Kerstin Göbel, Raimund W Kinne, Anker J Hansen, Thomas Budde, Christoph Kleinschnitz, Oliver Frey, Hans-Peter Tony, Heinz Wiendl, Sven G Meuth Arthritis Research & Therapy 2011, 13:R21 (11 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis Muneaki Ishijima, Taiji Watari, Kiyohito Naito, Haruka Kaneko, Ippei Futami, Kaori Yoshimura-Ishida, Akihito Tomonaga, Hideyo Yamaguchi, Tetsuro Yamamoto, Isao Nagaoka, Hisashi Kurosawa, Robin A Poole, Kazuo Kaneko Arthritis Research & Therapy 2011, 13:R22 (14 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000
	Research article Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta Catherine Baugé, Olivier Cauvard, Sylvain Leclercq, Philippe Galéra, Karim Boumédiene Arthritis Research & Therapy 2011, 13:R23 (15 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Tumor necrosis factor-alpha promotes survival in methotrexate-exposed macrophages by an NF-kappaB-dependent pathway Susan ZY Lo, James H Steer, David A Joyce Arthritis Research & Therapy 2011, 13:R24 (15 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-α inhibitors Regina Rendas-Baum, Gene V Wallenstein, Tamas Koncz, Mark Kosinski, Min Yang, John Bradley, Samuel H Zwillich Arthritis Research & Therapy 2011, 13:R25 (16 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese Dongquan Shi, Jin Dai, Pengsheng Zhu, Jianghui Qin, Lunqing Zhu, Hongtao Zhu, Baocheng Zhao, Xusheng Qiu, Zhihong Xu, Dongyang Chen, Long Yi, Shiro Ikegawa, Qing Jiang Arthritis Research & Therapy 2011, 13:R27 (17 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Effects of rehabilitative interventions on pain, function and physical impairments in people with hand osteoarthritis: a systematic review Liuzhen Ye, Leonid Kalichman, Alicia Spittle, Fiona Dobson, Kim Bennell Arthritis Research & Therapy 2011, 13:R28 (18 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Rehabilitative interventions such as exercise, splints, laser therapy and massage can improve pain, hand function, grip strength and range of motion in individuals with hand osteoarthritis.
	Research article Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4⁺CCR6⁺Th/Treg cell subset imbalance in ankylosing spondylitis Yanfeng Wu, Mingliang Ren, Rui Yang, Xinjun Liang, Yuanchen Ma, Yong Tang, Lin Huang, Jichao Ye, Keng Chen, Peng Wang, Huiyong Shen Arthritis Research & Therapy 2011, 13:R29 (21 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden Catharina Eriksson, Heidi Kokkonen, Martin Johansson, Göran Hallmans, Göran Wadell, Solbritt Rantapää-Dahlqvist Arthritis Research & Therapy 2011, 13:R30 (22 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Early changes in bone mineral density measured by digital X-ray radiogrammetry predict up to 20 years radiological outcome in rheumatoid arthritis Meliha C Kapetanovic, Elisabet Lindqvist, Jakob Algulin, Kjell Jonsson, Tore Saxne, Kerstin Eberhardt, Pierre Geborek Arthritis Research & Therapy 2011, 13:R31 (23 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Rheumatoid arthritis patients with marked bone mineral density (BMD) loss early in the disease course had significantly worse progression of joint damage during the 20-year follow-up period of this cohort study.
	Research article Validation of rheumatoid arthritis diagnoses in health care utilization data Seo Young Kim, Amber Servi, Jennifer M Polinski, Helen Mogun, Michael E Weinblatt, Jeffrey N Katz, Daniel H Solomon Arthritis Research & Therapy 2011, 13:R32 (23 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures Sinéad Nic An Ultaigh, Tajvur P Saber, Jennifer McCormick, Mary Connolly, Jerome Dellacasagrande, Brian Keogh, William McCormack, Mary Reilly, Luke A O'Neill, Peter McGuirk, Ursula Fearon, Douglas J Veale Arthritis Research & Therapy 2011, 13:R33 (23 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A novel monoclonal antibody that inhibits Toll-like receptor 2 significantly decreased spontaneous cytokine production from rheumatoid arthritis (RA) synovial tissue explant cultures, with an inhibitory effect comparable to adalimumab.
	Research article Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS) Jasmin B Kuemmerle-Deschner, Eduardo Ramos, Norbert Blank, Joachim Roesler, Sandra D Felix, Thomas Jung, Kirstin Stricker, Abhijit Chakraborty, Stacey Tannenbaum, Andrew M Wright, Christiane Rordorf Arthritis Research & Therapy 2011, 13:R34 (28 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Histopathological cutaneous alterations in systemic sclerosis: a clinicopathological study Jens T Van Praet, Vanessa Smith, Marc Haspeslagh, Nele Degryse, Dirk Elewaut, Filip De Keyser Arthritis Research & Therapy 2011, 13:R35 (28 February 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A number of histopathological parameters are associated with local clinical skin disease, but systemic sclerosis (SSc) specific histological alterations, although useful diagnostic markers, have a low sensitivity.
	Correspondence
	Letter Response to: Comparison of laser Doppler imaging, fingertip lacticemy test, and nailfold capillaroscopy for assessment of digital microcirculation in systemic sclerosis Alberto Sulli, Vanessa Smith, Maurizio Cutolo Arthritis Research & Therapy 2011, 13:301 (24 January 2011) Abstract \| Full text \| PDF \| PubMed
	Letter Response to: Comparison of laser Doppler imaging, fingertip lacticemy test, and nailfold capillaroscopy for assessment of digital microcirculation in systemic sclerosis - authors' reply Marcelo JU Correa, Luis EC Andrade, Cristiane Kayser Arthritis Research & Therapy 2011, 13:302 (24 January 2011) Abstract \| Full text \| PDF \| PubMed

	Volume 13 Issue 1
	Comment
	Editorial Molecular targets of natural health products in arthritis Sarah Khalifé, Muhammad Zafarullah Arthritis Research & Therapy 2011, 13:102 (3 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Editorial Nordic walking in fibromyalgia: a means of promoting fitness that is easy for busy clinicians to recommend Kim Jones Arthritis Research & Therapy 2011, 13:103 (16 February 2011) Abstract \| Full text \| PDF \| PubMed
	Commentary Promise and pitfalls of the Immunochip Adrian Cortes, Matthew A Brown Arthritis Research & Therapy 2011, 13:101 (1 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review
	Review A window on disease pathogenesis and potential therapeutic strategies: molecular imaging for arthritis Luke L Gompels, Ewa M Paleolog Arthritis Research & Therapy 2011, 13:201 (31 January 2011) Abstract \| Full text \| PDF \| PubMed
	Review Managing pregnancy in inflammatory rheumatological diseases Varsha Jain, Caroline Gordon Arthritis Research & Therapy 2011, 13:206 (25 February 2011) Abstract \| Full text \| PDF \| PubMed
	Review Disturbances of apoptotic cell clearance in systemic lupus erythematosus Wen-Hai Shao, Philip L Cohen Arthritis Research & Therapy 2011, 13:202 (28 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Review The interplay of inflammation and cardiovascular disease in systemic lupus erythematosus J Michelle Kahlenberg, Mariana J Kaplan Arthritis Research & Therapy 2011, 13:203 (28 February 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Kahlenberg and Kaplan describe the interplay of cardiac risk factors and systemic lupus erythematosus (SLE)-specific mechanisms in the development of accelerated atherosclerosis in SLE patients and discuss potential therapeutic targets.
	Review In vivo approaches to investigate ANCA-associated vasculitis: lessons and limitations Peter Heeringa, Mark A Little Arthritis Research & Therapy 2011, 13:204 (28 February 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary This review article explores the advantages and limitations of animal models currently used to investigate the unique pathogenic mechanisms involved in anti-neutrophil cytoplasm antibody-associated vasculitis.
	Review What have we learned from clinical trials in primary Sjögren's syndrome about pathogenesis? Cees GM Kallenberg, Arjan Vissink, Frans GM Kroese, Wayel H Abdulahad, Hendrika Bootsma Arthritis Research & Therapy 2011, 13:205 (28 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research
	Research article Validating English- and Spanish-language patient-reported outcome measures in underserved patients with rheumatic disease Gwenyth R Wallen, Kimberly R Middleton, Migdalia V Rivera-Goba, Barbara B Mittleman Arthritis Research & Therapy 2011, 13:R1 (5 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Salivary glands of primary Sjögren's syndrome patients express factors vital for plasma cell survival Ewa A Szyszko, Karl A Brokstad, Gunnvor Øijordsbakken, Malin V Jonsson, Roland Jonsson, Kathrine Skarstein Arthritis Research & Therapy 2011, 13:R2 (7 January 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts Sandeep K Agarwal, Minghua Wu, Christopher K Livingston, Donald H Parks, Maureen D Mayes, Frank C Arnett, Filemon K Tan Arthritis Research & Therapy 2011, 13:R3 (11 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Joint and tendon subclinical involvement suggestive of gouty arthritis in asymptomatic hyperuricemia: an ultrasound controlled study Carlos Pineda, Luis M Amezcua-Guerra, Carla Solano, Pedro Rodriguez-Henríquez, Cristina Hernández-Díaz, Angelica Vargas, Fritz Hofmann, Marwin Gutiérrez Arthritis Research & Therapy 2011, 13:R4 (17 January 2011) Abstract \| Full text \| PDF \| PubMed
	Research article (Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis Debby den Uyl, Mike T Nurmohamed, Lilian HD van Tuyl, Hennie G Raterman, Willem F Lems Arthritis Research & Therapy 2011, 13:R5 (17 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Individuals with subclinical cardiovascular disease are at greater risk of bone loss and subsequent fractures, suggesting the need for bone density screening in patients with this disease.
	Research article mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis Matthew R McCann, Roxana Monemdjou, Parisa Ghassemi-Kakroodi, Hassan Fahmi, Gemma Perez, Shangxi Liu, Xu Shi-wen, Sunil K Parapuram, Fumiaki Kojima, Christopher P Denton, David J Abraham, Johanne Martel-Pelletier, Leslie J Crofford, Andrew Leask, Mohit Kapoor Arthritis Research & Therapy 2011, 13:R6 (25 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy - a single centre, open-label study Eliza K Pontifex, Danielle M Gerlag, Martina Gogarty, Marjolein Vinkenoog, Adrian Gibbs, Ilse Burgman, Ursula Fearon, Barry Bresnihan, Paul Tak, Robin G Gibney, Douglas J Veale, Oliver FitzGerald Arthritis Research & Therapy 2011, 13:R7 (27 January 2011) Abstract \| Full text \| PDF \| PubMed
	Research article The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration Hamish TJ Gilbert, Judith A Hoyland, Anthony J Freemont, Sarah J Millward-Sadler Arthritis Research & Therapy 2011, 13:R8 (28 January 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Anti-class a scavenger receptor autoantibodies from systemic lupus erythematosus patients impair phagocytic clearance of apoptotic cells by macrophages in vitro Xiao-wei Chen, Yan Shen, Chuan-yin Sun, Feng-xia Wu, Yi Chen, Cheng-de Yang Arthritis Research & Therapy 2011, 13:R9 (31 January 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Mannose-binding lectin does not explain the course and outcome of pregnancy in rheumatoid arthritis Fleur E van de Geijn, Yaël A de Man, Manfred Wuhrer, Sten P Willemsen, André M Deelder, Johanna MW Hazes, Radboud JEM Dolhain Arthritis Research & Therapy 2011, 13:R10 (31 January 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population Ling-hong Liao, Hao Zhang, Man-Po Lai, Shun-Le Chen, Madeline Wu, Nan Shen Arthritis Research & Therapy 2011, 13:R11 (31 January 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis Anne Hinks, Paul Martin, Edward Flynn, Steve Eyre, Jon Packham, Childhood Arthritis Prospective Study (CAPS), BSPAR study group, Anne Barton, Jane Worthington, Wendy Thomson Arthritis Research & Therapy 2011, 13:R12 (31 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis Heidi Kokkonen, Mohammed Mullazehi, Ewa Berglin, Göran Hallmans, Göran Wadell, Johan Rönnelid, Solbritt Rantapää-Dahlqvist Arthritis Research & Therapy 2011, 13:R13 (3 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Dual role of interleukin-17 in pannus growth and osteoclastogenesis in rheumatoid arthritis Hiroshi Ito, Hidehiro Yamada, Toshiko N Shibata, Hirofumi Mitomi, So Nomoto, Shoichi Ozaki Arthritis Research & Therapy 2011, 13:R14 (4 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article A polymorphism in the interleukin-4 receptor affects the ability of interleukin-4 to regulate Th17 cells: a possible immunoregulatory mechanism for genetic control of the severity of rheumatoid arthritis Susan K Wallis, Laura A Cooney, Judith L Endres, Min Jie Lee, Jennifer Ryu, Emily C Somers, David A Fox Arthritis Research & Therapy 2011, 13:R15 (4 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Bone mineral density and body composition in postmenopausal women with psoriasis and psoriatic arthritis Paulo G Pedreira, Marcelo M Pinheiro, Vera L Szejnfeld Arthritis Research & Therapy 2011, 13:R16 (7 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Follistatin-like protein 1 is elevated in systemic autoimmune diseases and correlated with disease activity in patients with rheumatoid arthritis Dawei Li, Yuji Wang, Nanwei Xu, Qianghua Wei, Min Wu, Xiaofeng Li, Ping Zheng, Sai Sun, Yuli Jin, Gailian Zhang, Ruomin Liao, Ping Zhang Arthritis Research & Therapy 2011, 13:R17 (8 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis Bradley J Rabquer, Pei-Suen Tsou, Yong Hou, Eshwar Thirunavukkarasu, G Kenneth Haines, Ann J Impens, Kristine Phillips, Bashar Kahaleh, James R Seibold, Alisa E Koch Arthritis Research & Therapy 2011, 13:R18 (8 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Diagnostic properties of metabolic perturbations in rheumatoid arthritis Rasmus K Madsen, Torbjörn Lundstedt, Jon Gabrielsson, Carl-Johan Sennbro, Gerd-Marie Alenius, Thomas Moritz, Solbritt Rantapää-Dahlqvist, Johan Trygg Arthritis Research & Therapy 2011, 13:R19 (8 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Diagnostic value and clinical laboratory associations of antibodies against recombinant ribosomal P0, P1 and P2 proteins and their native heterocomplex in a Caucasian cohort with systemic lupus erythematosus Fidan Barkhudarova, Cornelia Dähnrich, Anke Rosemann, Udo Schneider, Winfried Stöcker, Gerd-Rüdiger Burmester, Karl Egerer, Wolfgang Schlumberger, Falk Hiepe, Robert Biesen Arthritis Research & Therapy 2011, 13:R20 (10 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Anti-dsDNA-NcX ELISA: dsDNA-loaded nucleosomes improve diagnosis and monitoring of disease activity in systemic lupus erythematosus Robert Biesen, Cornelia Dähnrich, Anke Rosemann, Fidan Barkhudarova, Thomas Rose, Olga Jakob, Anne Bruns, Marina Backhaus, Winfried Stöcker, Gerd-Rüdiger Burmester, Wolfgang Schlumberger, Karl Egerer, Falk Hiepe Arthritis Research & Therapy 2011, 13:R26 (10 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Expression of K_2P5.1 potassium channels on CD4⁺T lymphocytes correlates with disease activity in rheumatoid arthritis patients Stefan Bittner, Nicole Bobak, Martin Feuchtenberger, Alexander M Herrmann, Kerstin Göbel, Raimund W Kinne, Anker J Hansen, Thomas Budde, Christoph Kleinschnitz, Oliver Frey, Hans-Peter Tony, Heinz Wiendl, Sven G Meuth Arthritis Research & Therapy 2011, 13:R21 (11 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis Muneaki Ishijima, Taiji Watari, Kiyohito Naito, Haruka Kaneko, Ippei Futami, Kaori Yoshimura-Ishida, Akihito Tomonaga, Hideyo Yamaguchi, Tetsuro Yamamoto, Isao Nagaoka, Hisashi Kurosawa, Robin A Poole, Kazuo Kaneko Arthritis Research & Therapy 2011, 13:R22 (14 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000
	Research article Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta Catherine Baugé, Olivier Cauvard, Sylvain Leclercq, Philippe Galéra, Karim Boumédiene Arthritis Research & Therapy 2011, 13:R23 (15 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Tumor necrosis factor-alpha promotes survival in methotrexate-exposed macrophages by an NF-kappaB-dependent pathway Susan ZY Lo, James H Steer, David A Joyce Arthritis Research & Therapy 2011, 13:R24 (15 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-α inhibitors Regina Rendas-Baum, Gene V Wallenstein, Tamas Koncz, Mark Kosinski, Min Yang, John Bradley, Samuel H Zwillich Arthritis Research & Therapy 2011, 13:R25 (16 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese Dongquan Shi, Jin Dai, Pengsheng Zhu, Jianghui Qin, Lunqing Zhu, Hongtao Zhu, Baocheng Zhao, Xusheng Qiu, Zhihong Xu, Dongyang Chen, Long Yi, Shiro Ikegawa, Qing Jiang Arthritis Research & Therapy 2011, 13:R27 (17 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Effects of rehabilitative interventions on pain, function and physical impairments in people with hand osteoarthritis: a systematic review Liuzhen Ye, Leonid Kalichman, Alicia Spittle, Fiona Dobson, Kim Bennell Arthritis Research & Therapy 2011, 13:R28 (18 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Rehabilitative interventions such as exercise, splints, laser therapy and massage can improve pain, hand function, grip strength and range of motion in individuals with hand osteoarthritis.
	Research article Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4⁺CCR6⁺Th/Treg cell subset imbalance in ankylosing spondylitis Yanfeng Wu, Mingliang Ren, Rui Yang, Xinjun Liang, Yuanchen Ma, Yong Tang, Lin Huang, Jichao Ye, Keng Chen, Peng Wang, Huiyong Shen Arthritis Research & Therapy 2011, 13:R29 (21 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden Catharina Eriksson, Heidi Kokkonen, Martin Johansson, Göran Hallmans, Göran Wadell, Solbritt Rantapää-Dahlqvist Arthritis Research & Therapy 2011, 13:R30 (22 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Early changes in bone mineral density measured by digital X-ray radiogrammetry predict up to 20 years radiological outcome in rheumatoid arthritis Meliha C Kapetanovic, Elisabet Lindqvist, Jakob Algulin, Kjell Jonsson, Tore Saxne, Kerstin Eberhardt, Pierre Geborek Arthritis Research & Therapy 2011, 13:R31 (23 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Rheumatoid arthritis patients with marked bone mineral density (BMD) loss early in the disease course had significantly worse progression of joint damage during the 20-year follow-up period of this cohort study.
	Research article Validation of rheumatoid arthritis diagnoses in health care utilization data Seo Young Kim, Amber Servi, Jennifer M Polinski, Helen Mogun, Michael E Weinblatt, Jeffrey N Katz, Daniel H Solomon Arthritis Research & Therapy 2011, 13:R32 (23 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research article Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures Sinéad Nic An Ultaigh, Tajvur P Saber, Jennifer McCormick, Mary Connolly, Jerome Dellacasagrande, Brian Keogh, William McCormack, Mary Reilly, Luke A O'Neill, Peter McGuirk, Ursula Fearon, Douglas J Veale Arthritis Research & Therapy 2011, 13:R33 (23 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A novel monoclonal antibody that inhibits Toll-like receptor 2 significantly decreased spontaneous cytokine production from rheumatoid arthritis (RA) synovial tissue explant cultures, with an inhibitory effect comparable to adalimumab.
	Research article Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS) Jasmin B Kuemmerle-Deschner, Eduardo Ramos, Norbert Blank, Joachim Roesler, Sandra D Felix, Thomas Jung, Kirstin Stricker, Abhijit Chakraborty, Stacey Tannenbaum, Andrew M Wright, Christiane Rordorf Arthritis Research & Therapy 2011, 13:R34 (28 February 2011) Abstract \| Full text \| PDF \| PubMed
	Research article Histopathological cutaneous alterations in systemic sclerosis: a clinicopathological study Jens T Van Praet, Vanessa Smith, Marc Haspeslagh, Nele Degryse, Dirk Elewaut, Filip De Keyser Arthritis Research & Therapy 2011, 13:R35 (28 February 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A number of histopathological parameters are associated with local clinical skin disease, but systemic sclerosis (SSc) specific histological alterations, although useful diagnostic markers, have a low sensitivity.
	Correspondence
	Letter Response to: Comparison of laser Doppler imaging, fingertip lacticemy test, and nailfold capillaroscopy for assessment of digital microcirculation in systemic sclerosis Alberto Sulli, Vanessa Smith, Maurizio Cutolo Arthritis Research & Therapy 2011, 13:301 (24 January 2011) Abstract \| Full text \| PDF \| PubMed
	Letter Response to: Comparison of laser Doppler imaging, fingertip lacticemy test, and nailfold capillaroscopy for assessment of digital microcirculation in systemic sclerosis - authors' reply Marcelo JU Correa, Luis EC Andrade, Cristiane Kayser Arthritis Research & Therapy 2011, 13:302 (24 January 2011) Abstract \| Full text \| PDF \| PubMed

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