Figure 1.

Pathways (receptors and ligands) leading to type I interferon production. DAI, DNA-dependent activator of interferon regulatory factors; HMGB, high-mobility group box protein; LPS, lipopolysaccharide; MDA5, melanoma differentiation-associated protein 5; RIG-I, retinoic acid inducible gene I; TLR, Toll-like receptor.