Table 4 |
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|
Odds ratios for associations between biomarker levels (baseline and changes from baseline to week 4) and outcome measures of fatigue (FACIT-F) and health-related quality of life (SF-36) at week 14 for the training and test golimumab/golimumab + MTX datasets |
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|
FACIT-F |
SF-36 PCS |
SF-36 MCS |
||||
|
|
||||||
|
OR |
P |
OR |
P |
OR |
P |
|
|
|
||||||
|
Training subset |
||||||
|
Baseline |
||||||
|
von Willebrand factor |
0.380 |
0.021 |
0.427 |
0.039 |
0.370 |
0.019 |
|
Change from baseline to week 4 |
||||||
|
ENRAGE (S100A12) |
0.578 |
0.053 |
0.549 |
0.044 |
0.603 |
0.070 |
|
Matrix metalloproteinase-3 |
0.529 |
0.041 |
0.621 |
0.122 |
1.000 |
0.999 |
|
Test subset |
||||||
|
Baseline |
||||||
|
Matrix metalloproteinase-3 |
1.233 |
0.035 |
0.922 |
0.409 |
0.972 |
0.775 |
|
Tissue inhibitor of metalloproteinase-1 |
0.925 |
0.843 |
0.375 |
0.017 |
0.798 |
0.567 |
|
Change from baseline to week 4 |
||||||
|
C-reactive protein |
0.879 |
0.122 |
0.772 |
0.003 |
0.833 |
0.033 |
|
Matrix metalloproteinase-3 |
0.893 |
0.522 |
0.811 |
0.248 |
0.615 |
0.010 |
|
All data combined |
||||||
|
Baseline |
||||||
|
α1-antitrypsin |
1.206 |
0.479 |
0.567 |
0.037 |
1.230 |
0.436 |
|
Intracellular adhesion molecule-1 |
1.166 |
0.484 |
0.611 |
0.046 |
1.451 |
0.117 |
|
Tissue inhibitor of metalloprotienases-1 |
0.833 |
0.583 |
0.342 |
0.002 |
0.843 |
0.610 |
|
von Willebrand factor |
0.949 |
0.775 |
0.628 |
0.017 |
0.760 |
0.146 |
|
Change from baseline to week 4 |
||||||
|
C-reactive protein |
0.910 |
0.176 |
0.831 |
0.011 |
0.940 |
0.370 |
|
ENRAGE (S100A12) |
0.761 |
0.040 |
0.710 |
0.011 |
0.821 |
0.135 |
|
Interleukin-6 |
0.953 |
0.543 |
0.846 |
0.039 |
0.965 |
0.651 |
|
Matrix metalloprotienase-3 |
0.810 |
0.173 |
0.784 |
0.121 |
0.669 |
0.013 |
|
|
||||||
|
Odds ratios show association between biomarker levels (baseline or changes from baseline to week 4) and whether FACIT-F, SF-36 mental component summary score, or SF-36 physical component summary score was above or below the median. Only biomarkers for which at least one association was <0.05 are shown. FACIT-F, Functional Assessment of Chronic Illness Therapy -Fatigue; SF-36, 36-question Short Form Survey; OR, odds ratio; MCS, mental component summary score; PCS, physical component summary score. |
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|
Visvanathan et al. Arthritis Research & Therapy 2010 12:R211 doi:10.1186/ar3188 |
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