Table 2

Associations between biomarker levels (baseline and changes from baseline to week 4) and clinical measures (ACR 20, ACR 50, and DAS 28 responses) at week 14 for golimumab/golimumab + MTX training and test datasets

ACR 20

ACR 50

DAS 28


OR

P

OR

P

OR

P


Training subset

Baseline

Pyridinoline

0.101

0.004

0.383

NS

0.150

NS

von Willebrand factor

0.444

0.048

0.366

0.026

0.420

NS

Change from baseline to week 4

α1-Antitrypsin

0.025

0.009

1.021

NS

0.138

NS

Complement 3

0.007

0.006

0.707

NS

0.324

NS

ENRAGE (S100A12)

0.455

0.015

0.841

NS

0.381

0.030

Haptoglobin

0.131

0.003

0.693

NS

0.276

0.033

Hyaluronic acid

0.343

0.006

0.975

NS

0.511

NS

Interleukin-8

0.483

NS

0.472

0.020

0.572

NS

Interleukin-16

0.121

0.012

1.041

NS

0.096

0.015

Matrix metalloproteinase-3

0.318

0.008

1.102

NS

0.283

NS

Plasminogen activator-1

0.114

0.041

0.713

NS

0.442

NS

Pyridinoline

3.744

NS

0.212

0.044

23.610

NS

Serum amyloid P

0.057

0.006

0.650

NS

0.075

0.035

Thyroxine-binding globulin

0.008

0.008

2.093

NS

0.221

NS

Test subset

Baseline

Apolipoprotein C3

0.753

NS

0.510

0.006

0.930

NS

Hyaluronic acid

1.347

0.001

1.228

0.037

1.102

NS

Interleukin-6

1.199

0.024

1.232

0.027

1.052

NS

Interleukin-8

0.880

NS

0.970

NS

0.802

0.042

Matrix metalloproteinase-3

1.240

0.026

1.181

NS

1.087

NS

Myeloperoxidase

0.821

NS

0.934

NS

0.694

0.020

Change from baseline to week 4

α1-Antitrypsin

0.505

NS

0.298

0.035

0.301

0.033

Apolipoprotein C3

2.191

0.014

1.681

NS

1.741

NS

Basic fibroblast growth factor

0.353

0.007

0.484

0.042

0.424

0.012

Carcinoembryonic antigen

2.674

NS

1.89

NS

3.891

0.020

C-reactive protein

0.714

<0.001

0.652

<0.001

0.728

0.002

ENRAGE (S100A12)

0.642

0.005

0.568

0.001

0.767

NS

Haptoglobin

0.497

0.004

0.417

<0.001

0.474

0.008

Hyaluronic acid

0.513

<0.001

0.514

<0.001

0.699

0.017

Interleukin-6

0.623

<0.001

0.665

<0.001

0.733

0.003

Interleukin-16

0.371

0.007

0.234

<0.001

0.422

0.029

Intracellular adhesion molecule-1

0.654

NS

0.673

NS

0.468

0.030

Lipoprotein (a)

0.727

NS

0.460

0.045

0.748

NS

Matrix metalloproteinase-3

0.539

0.001

0.570

0.005

0.673

0.043

Macrophage inflammatory protein 1-α

0.687

NS

0.454

0.041

0.903

NS

Serum amyloid P

0.628

NS

0.304

0.015

0.346

0.025

Stem cell factor

2.239

0.028

1.521

NS

1.383

NS

Tissue inhibitor of metalloproteinases-1

0.595

NS

0.264

0.035

0.603

NS

Vascular endothelial growth factor

0.419

0.009

0.326

0.004

0.307

0.002


Only biomarkers are shown for which P < 0.05 for associations with ACR 20 or ACR 50 responses at each point. ACR, American College of Rheumatology; DAS, disease activity score; OR, odds ratio; MTX, methotrexate; NS, not significant.

Visvanathan et al. Arthritis Research & Therapy 2010 12:R211   doi:10.1186/ar3188

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