Table 4

Risk of mortality and cardiovascular disease associated with gout

Study estimate (95% CI)

Design

Population

Comparison

Multivariate risk


All-cause mortality

HPFS [73]

Cohort: stratified by baseline CHD status

51,927 male health professionals, 40 to 75 years old

CHD: gout vs. no gout

RR = 1.25 (1.09, 1.45)

No CHD: gout vs. no gout

RR = 1.28 (1.15, 1.41)

MRFIT [74]

MRFIT RCT participants

9,105 men, 41 to 63 years old

Gout vs. no gout

HR = 1.09 (1.00, 1.19)

CGMH [75]

Cohort: health screening programme participants

61,527 men and women, 30 to 74 years old

Gout vs. normouricaemia

HR = 1.46 (1.12, 1.91)

All cardiovascular death

HPFS [73]

Cohort: stratified by baseline CHD status

51,927 male health professionals, 40 to 75 years old

CHD: gout vs. no gout

RR = 1.26 (1.07, 1.50)

No CHD: gout vs. no gout

RR = 1.38 (1.15, 1.66)

MRFIT [74]

MRFIT RCT participants

9,105 men, 41 to 63 years old

Gout vs. no gout

HR = 1.21 (0.99, 1.49)

CGMH [75]

Cohort: health screening programme participants

61,527 men and women, 30 to 74 years old

Gout vs. normouricaemia

HR = 1.97 (1.08, 3.59)

Fatal CHD

HPFS [73]

Cohort: stratified by baseline CHD status

51,927 male health professionals, 40 to 75 years old

CHD: gout vs. no gout

RR = 1.24 (1.04, 1.49)

No CHD: gout vs. no gout

RR = 1.55 (1.24, 1.93)

MRFIT [74]

MRFIT RCT participants

9,105 men, 41 to 63 years old

Gout vs. no gout

HR = 1.35 (1.06, 1.72)

Fatal myocardial infarction

MRFIT [74]

MRFIT RCT participants

9,105 men, 41 to 63 years old

Gout vs. no gout

HR = 1.35 (0.94, 1.93)

Cardiovascular disease

Dutch primary care [76]

Follow-up of case-control study participants

261 men and women

Gout vs. no gout

RR = 0.98 (0.65, 1.47)

Coronary heart disease

Framingham Study [78]

Cohort

2,316 men

Gout vs. no gout

RR = 1.6 (1.1, 2.5)

Meharry-Hopkins Study [77]

Cohort

1,552 male physicians

Gout vs. no gout

RR = 0.59 (0.24, 1.46)

GPRD [13]

Case-control

207,350 men and women

Gout vs. osteoarthritis

OR = 1.75 (1.70, 1.79)

Myocardial infarction

Framingham Study [78]

Cohort

2,316 men

Gout vs. no gout

RR = 1.5 (0.9, 2.6)

MRFIT [79]

MRFIT RCT participants

12,866 men

Gout vs. no gout

OR = 1.26 (1.14, 1.40)

Angina pectoris

Framingham Study [78]

Cohort

2,316 men

Gout vs. no gout

RR = 1.8 (1.1, 3.2)


CGMH, Chang Gung Memorial Hospital; CHD, coronary heart disease; CI, confidence interval; GPRD, General Practice Research Database; HPFS, Health Professionals Follow-up Study; HR, hazard ratio; MRFIT, Multiple Risk Factor Intervention Trial; OR, odds ratio; RCT, randomised controlled trial; RR, relative risk.

Roddy and Doherty Arthritis Research & Therapy 2010 12:223   doi:10.1186/ar3199