Table 2

Integrated Discomfort Score

Disease score

Characteristics

Monitoring

Maximal durationa


0

Asymptomatic

Daily

End of experiment

No general discomfort signs

0.5

Fever ( > 0.5°C)

Twice per week

12 weeks

1

Apathy

Daily

10 weeks

Less mobility but no pain

Daily

Loss of appetite

Daily

2

Weight loss

Twice per week

6 weeks

Warm extremities

Twice per week

Treatable pain without STS

Daily

3

Moderate redness + STS of joints

Twice per week

4 weeks

Normal flexibility of extremities

Twice per week

4

Severe redness + STS of joints

Twice per week

2 weeks

With joint stiffness

5

Serious lethargy

Daily

18 hours

Serious untreatable pain

Daily

18 hours

Serious immobility of joints

Twice per week

18 hoursb

Body weight loss >25%

Twice per week

18 hoursb


STS, soft tissue swelling. aThe discomfort time combination is used in a cumulative fashion. bCan only be assessed in the sedated monkey, which cannot be done more than twice per week for ethical reasons.

Vierboom et al. Arthritis Research & Therapy 2010 12:R200   doi:10.1186/ar3172

Open Data