Table 2 |
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|
Integrated Discomfort Score |
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|
Disease score |
Characteristics |
Monitoring |
Maximal durationa |
|
|
|||
|
0 |
Asymptomatic |
Daily |
End of experiment |
|
No general discomfort signs |
|||
|
0.5 |
Fever ( > 0.5°C) |
Twice per week |
12 weeks |
|
1 |
Apathy |
Daily |
10 weeks |
|
Less mobility but no pain |
Daily |
||
|
Loss of appetite |
Daily |
||
|
2 |
Weight loss |
Twice per week |
6 weeks |
|
Warm extremities |
Twice per week |
||
|
Treatable pain without STS |
Daily |
||
|
3 |
Moderate redness + STS of joints |
Twice per week |
4 weeks |
|
Normal flexibility of extremities |
Twice per week |
||
|
4 |
Severe redness + STS of joints |
Twice per week |
2 weeks |
|
With joint stiffness |
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|
5 |
Serious lethargy |
Daily |
18 hours |
|
Serious untreatable pain |
Daily |
18 hours |
|
|
Serious immobility of joints |
Twice per week |
18 hoursb |
|
|
Body weight loss >25% |
Twice per week |
18 hoursb |
|
|
|
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|
STS, soft tissue swelling. aThe discomfort time combination is used in a cumulative fashion. bCan only be assessed in the sedated monkey, which cannot be done more than twice per week for ethical reasons. |
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|
Vierboom et al. Arthritis Research & Therapy 2010 12:R200 doi:10.1186/ar3172 |
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