Table 4

Summary of AMG 108 trough concentration (nM) at 20 and 24 weeks

50 mg AMG 108

125 mg AMG 108

250 mg AMG 108


Week 20 (n = 144)

Week 24 (n = 137)

Week 20 (n = 146)

Week 24 (n = 140)

Week 20 (n = 137)

Week 24 (n = 138)


Mean

0

0

16.5

19.8

155

160

Median

0

0

6.25

4.65

139

141

Range

0 to 6.43

0 to 0.32

0 to 104

0 to 268

0 to 417

0 to 1,000


Below quantifiable levels reported as 0. 90% inhibitory concentration = 13.5 nM, 50% inhibitory concentration = 1.5 nM.

Cardiel et al. Arthritis Research & Therapy 2010 12:R192   doi:10.1186/ar3163

Open Data