Table 4 |
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|
Summary of AMG 108 trough concentration (nM) at 20 and 24 weeks |
||||||
|
50 mg AMG 108 |
125 mg AMG 108 |
250 mg AMG 108 |
||||
|
|
||||||
|
Week 20 (n = 144) |
Week 24 (n = 137) |
Week 20 (n = 146) |
Week 24 (n = 140) |
Week 20 (n = 137) |
Week 24 (n = 138) |
|
|
|
||||||
|
Mean |
0 |
0 |
16.5 |
19.8 |
155 |
160 |
|
Median |
0 |
0 |
6.25 |
4.65 |
139 |
141 |
|
Range |
0 to 6.43 |
0 to 0.32 |
0 to 104 |
0 to 268 |
0 to 417 |
0 to 1,000 |
|
|
||||||
|
Below quantifiable levels reported as 0. 90% inhibitory concentration = 13.5 nM, 50% inhibitory concentration = 1.5 nM. |
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|
Cardiel et al. Arthritis Research & Therapy 2010 12:R192 doi:10.1186/ar3163 |
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