Table 3

Improvements in American College of Rheumatology and DAS28 components at week 24

AMG 108

Placebo

(n = 203)

50 mg

(n = 204)

125 mg

(n = 203)

250 mg

(n = 203)

Tender joint count (68 joints)

Mean (SD) % change

-20.0 (127.5)

-29.5 (60.4)

-35.7 (43.6)

-40.2 (44.3)

Median % change

-31.3

-38.4

-40.0

-46.7

Swollen joint count (66 joints)

Mean (SD) % change

-32.2 (50.0)

-33.7 (46.5)

-33.8 (114.8)

-39.1 (53.3)

Median % change

-33.1

-40.8

-46.3

-47.1

Patient global assessment

Mean (SD) % change

-11.6 (49.8)

-16.7 (43.8)

-21.6 (48.2)

-17.8 (64.5)

Median % change

-20.0

-16.7

-28.6

-20.0

Physician global assessment

Mean (SD) % change

-30.1 (33.7)

-36.0 (30.4)

-36.2 (33.2)

-43.0 (30.8)

Median % change

-33.3

-37.5

-40.0

-50.0

Pain (visual analog scale)

Mean (SD) % change

2.2 (142.6)

-11.4 (76.3)

-20.6 (60.6)

-30.9 (46.9)

Median % change

-12.8

-20.0

-28.9

-34.7

HAQ Disability Index

Mean (SD) % change

-11.1 (53.0)

-12.2 (40.6)

-20.5 (48.2)

-25.2 (44.6)

Median % change

-11.4

-13.3

-20.0

-25.0

Erythrocyte sedimentation rate

Mean (SD) % change

12.7 (77.7)

5 (124.3)

-18.3 (68.7)

-30.4 (73.7)

Median % change

-6.3

-13.2

-36.8

-46.7

C-reactive protein

Mean (SD) % change

123.2 (695.3)

32.2 (164.0)

-1.9 (181.5)

-25.5 (168.5)

Median % change

5.1

-12.4

-41.2

-59.4

Tender joint count (28 joints)

Mean (SD) % change

-13.2 (143.7)

-21.0 (73.2)

-31.6 (58.7)

-36.5 (65.7)

Median % change

-33.3

-33.3

-40.0

-44.4

Swollen joint count (28 joints)

Mean (SD) % change

-28.2 (52.7)

-30.0 (48.1)

-28.7 (118.3)

-38.0 (52.2)

Median % change

-33.3

-33.3

-44.4

-44.4

DAS28, Disease Activity Score (28-joint count); HAQ, health assessment questionnaire; SD, standard deviation.

Cardiel et al. Arthritis Research & Therapy 2010 12:R192   doi:10.1186/ar3163