Table 1 |
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|
Baseline demographics and disease characteristics |
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|
AMG 108 |
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|
|
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|
Placebo (n = 203) |
50 mg (n = 204) |
125 mg (n = 203) |
250 mg (n = 203) |
Total (n = 610) |
|
|
|
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|
Mean age (years) |
52.1 |
51.4 |
51.7 |
52.2 |
51.8 |
|
Age group, n (%) |
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|
< 65 years |
185 (91.1) |
171 (83.8) |
176 (86.7) |
184 (90.6) |
531 (87.0) |
|
≥65 years |
18 (8.9) |
33 (16.2) |
27 (13.3) |
19 (9.4) |
79 (13.0) |
|
Female, n (%) |
158 (77.8) |
155 (76.0) |
163 (80.3) |
160 (78.8) |
478 (78.4) |
|
Ethnicity, n (%) |
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|
White |
168 (82.8) |
169 (82.8) |
177 (87.2) |
179 (88.2) |
525 (86.1) |
|
Hispanic |
27 (13.3) |
24 (11.8) |
18 (8.9) |
17 (8.4) |
59 (9.7) |
|
Othera |
8 (3.9) |
11 (5.4) |
8 (3.9) |
7 (3.4) |
26 (4.3) |
|
Mean weight (kg) |
76.4 |
77.2 |
74.2 |
75.0 |
75.4 |
|
Mean height (cm) |
164.0 |
164.6 |
164.0 |
164.8 |
164.5 |
|
Mean body mass index (kg/m2) |
28.4 |
28.4 |
27.5 |
27.5 |
27.8 |
|
Mean duration of RA (years) |
7.6 |
7.3 |
7.5 |
8.0 |
7.6 |
|
Subcomponent of ACR (mean) |
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|
Tender joint count |
26.3 |
26.5 |
24.8 |
26.9 |
26.1 |
|
Swollen joint count |
16.8 |
16.8 |
15.8 |
15.7 |
16.1 |
|
Patient global assessment |
5.9 |
6.2 |
6.1 |
6.1 |
6.2 |
|
Physician global assessment |
6.2 |
6.3 |
6.3 |
6.5 |
6.4 |
|
Patient pain assessment |
51.2 |
53.9 |
53.5 |
57.0 |
54.8 |
|
HAQ Disability Index |
1.4 |
1.5 |
1.5 |
1.5 |
1.5 |
|
C-reactive protein (mg/dl) |
1.2 |
1.8 |
1.5 |
1.4 |
1.6 |
|
ESR (mm/hour) |
33.4 |
40.1 |
35.6 |
35.5 |
37.1 |
|
Mean DAS28 CRP |
4.7 |
4.9 |
4.7 |
4.8 |
4.8 |
|
Mean DAS28 ESR |
5.3 |
5.4 |
5.3 |
5.4 |
5.3 |
|
Mean tender joint count (28 joints) |
14.0 |
14.5 |
13.5 |
14.0 |
14.0 |
|
Mean swollen joint count (28 joints) |
11.3 |
10.6 |
10.8 |
11.2 |
11.0 |
|
|
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|
ACR, American College of Rheumatology; DAS28, Disease Activity Score (28-joint count); ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; RA, rheumatoid arthritis. aBlack, Asian, American Indian or Alaska native, native Hawaiian or other Pacific Islander. |
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|
Cardiel et al. Arthritis Research & Therapy 2010 12:R192 doi:10.1186/ar3163 |
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