Table 1

Baseline demographics and disease characteristics

AMG 108


Placebo

(n = 203)

50 mg

(n = 204)

125 mg

(n = 203)

250 mg

(n = 203)

Total

(n = 610)


Mean age (years)

52.1

51.4

51.7

52.2

51.8

Age group, n (%)

< 65 years

185 (91.1)

171 (83.8)

176 (86.7)

184 (90.6)

531 (87.0)

≥65 years

18 (8.9)

33 (16.2)

27 (13.3)

19 (9.4)

79 (13.0)

Female, n (%)

158 (77.8)

155 (76.0)

163 (80.3)

160 (78.8)

478 (78.4)

Ethnicity, n (%)

White

168 (82.8)

169 (82.8)

177 (87.2)

179 (88.2)

525 (86.1)

Hispanic

27 (13.3)

24 (11.8)

18 (8.9)

17 (8.4)

59 (9.7)

Othera

8 (3.9)

11 (5.4)

8 (3.9)

7 (3.4)

26 (4.3)

Mean weight (kg)

76.4

77.2

74.2

75.0

75.4

Mean height (cm)

164.0

164.6

164.0

164.8

164.5

Mean body mass index (kg/m2)

28.4

28.4

27.5

27.5

27.8

Mean duration of RA (years)

7.6

7.3

7.5

8.0

7.6

Subcomponent of ACR (mean)

Tender joint count

26.3

26.5

24.8

26.9

26.1

Swollen joint count

16.8

16.8

15.8

15.7

16.1

Patient global assessment

5.9

6.2

6.1

6.1

6.2

Physician global assessment

6.2

6.3

6.3

6.5

6.4

Patient pain assessment

51.2

53.9

53.5

57.0

54.8

HAQ Disability Index

1.4

1.5

1.5

1.5

1.5

C-reactive protein (mg/dl)

1.2

1.8

1.5

1.4

1.6

ESR (mm/hour)

33.4

40.1

35.6

35.5

37.1

Mean DAS28 CRP

4.7

4.9

4.7

4.8

4.8

Mean DAS28 ESR

5.3

5.4

5.3

5.4

5.3

Mean tender joint count (28 joints)

14.0

14.5

13.5

14.0

14.0

Mean swollen joint count (28 joints)

11.3

10.6

10.8

11.2

11.0


ACR, American College of Rheumatology; DAS28, Disease Activity Score (28-joint count); ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; RA, rheumatoid arthritis. aBlack, Asian, American Indian or Alaska native, native Hawaiian or other Pacific Islander.

Cardiel et al. Arthritis Research & Therapy 2010 12:R192   doi:10.1186/ar3163

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