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Volume 12 Issue 5
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Comment |
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Sizing up stability: combination therapy with Apo-AI peptide mimetics and statins in systemic lupus erythematosus-mediated atherosclerosis
Yanice Mendez-Fernandez, Amy Major Arthritis Research & Therapy 2010, 12:139 (15 September 2010)
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Advances in gout: some answers, more questions
Jasvinder A Singh Arthritis Research & Therapy 2010, 12:136 (24 September 2010)
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The increased cardiovascular risk in rheumatoid arthritis: when does it start?
Michael T Nurmohamed Arthritis Research & Therapy 2010, 12:140 (29 September 2010)
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Elevated excitatory neurotransmitter levels in the fibromyalgia brain
Richard E Harris Arthritis Research & Therapy 2010, 12:141 (1 October 2010)
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Histone deacetylases in RA: epigenetics and epiphenomena
Aleksander M Grabiec, Kris A Reedquist Arthritis Research & Therapy 2010, 12:142 (11 October 2010)
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Bone and cartilage in osteoarthritis: is what's best for one good or bad for the other?
Steven R Goldring, Mary B Goldring Arthritis Research & Therapy 2010, 12:143 (19 October 2010)
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Rethinking the red wolf disease: does Protein S suppress systemic lupus erythematosus clinical activity?
Gregg J Silverman Arthritis Research & Therapy 2010, 12:144 (27 October 2010)
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Interleukin-6: a local pain trigger?
Camilla I Svensson Arthritis Research & Therapy 2010, 12:145 (28 October 2010)
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The cytokine language of monocytes and macrophages in systemic sclerosis
Romy B Christmann, Robert Lafyatis Arthritis Research & Therapy 2010, 12:146 (29 October 2010)
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Review |
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Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders
Rita Dreier Arthritis Research & Therapy 2010, 12:216 (16 September 2010)
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The effect of immunomodulators on the immunogenicity of TNF-blocking therapeutic monoclonal antibodies: a review
Charlotte Krieckaert, Geertje Bartelds, Willem Lems, Gerrit Wolbink Arthritis Research & Therapy 2010, 12:217 (20 October 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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The association between rheumatoid arthritis and periodontal disease
Jacqueline Detert, Nicole Pischon, Gerd R Burmester, Frank Buttgereit Arthritis Research & Therapy 2010, 12:218 (22 October 2010)
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Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance
Tineke Cantaert, Dominique Baeten, Paul P Tak, Lisa GM van Baarsen Arthritis Research & Therapy 2010, 12:219 (28 October 2010)
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Research |
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Predictors of interstitial lung disease in early systemic sclerosis: a prospective longitudinal study of the GENISOS cohort
Shervin Assassi, Roozbeh Sharif, Robert E Lasky, Terry A McNearney, Rosa M Estrada-Y-Martin, Hilda Draeger, Deepthi K Nair, Marvin J Fritzler, John D Reveille, Frank C Arnett, Maureen D Mayes, the GENISOS Study Group Arthritis Research & Therapy 2010, 12:R166 (2 September 2010)
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Chondroprotective effects and mechanisms of resveratrol in advanced glycation end products-stimulated chondrocytes
Feng-Cheng Liu, Li-Feng Hung, Wan-Lin Wu, Deh-Ming Chang, Chuan-Yueh Huang, Jenn-Haung Lai, Ling-Jun Ho Arthritis Research & Therapy 2010, 12:R167 (8 September 2010)
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Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis
Junghee J Shin, Klemen Strle, Lisa J Glickstein, Andrew D Luster, Allen C Steere Arthritis Research & Therapy 2010, 12:R168 (9 September 2010)
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The Belgian MIRA (MabThera In Rheumatoid Arthritis) registry: clues for the optimization of rituximab treatment strategies
Bert Vander Cruyssen, Patrick Durez, Rene Westhovens, Marie-Joelle Kaiser, Ilse Hoffman, Filip De Keyser, The MIRA Study Group Arthritis Research & Therapy 2010, 12:R169 (10 September 2010)
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Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy
Ling-dong Quan, P Edward Purdue, Xin-ming Liu, Michael D Boska, Subodh M Lele, Geoffrey M Thiele, Ted R Mikuls, Huanyu Dou, Steven R Goldring, Dong Wang Arthritis Research & Therapy 2010, 12:R170 (13 September 2010)
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Assessment of myocardial abnormalities in rheumatoid arthritis using a comprehensive cardiac magnetic resonance approach: a pilot study
Yasuyuki Kobayashi, Jon T Giles, Masaharu Hirano, Isamu Yokoe, Yasuo Nakajima, Joan M Bathon, Joao AC Lima, Hitomi Kobayashi Arthritis Research & Therapy 2010, 12:R171 (13 September 2010)
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Editor’s summary
MRI-detected myocardial abnormalities were associated with higher rheumatoid arthritis (RA) disease activity in patients without known cardiac disease, suggesting a role for inflammation in the pathogenesis of myocardial involvement in RA.
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Longitudinal assessment of cyst-like lesions of the knee and their relation to radiographic osteoarthritis and MRI-detected effusion and synovitis in patients with knee pain
Daichi Hayashi, Frank W Roemer, Zineb Dhina, C Kent Kwoh, Michael J Hannon, Carolyn Moore, Ali Guermazi Arthritis Research & Therapy 2010, 12:R172 (15 September 2010)
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Fully automated system for the quantification of human osteoarthritic knee joint effusion volume using magnetic resonance imaging
Wei Li, François Abram, Jean-Pierre Pelletier, Jean-Pierre Raynauld, Marc Dorais, Marc-André d'Anjou, Johanne Martel-Pelletier Arthritis Research & Therapy 2010, 12:R173 (16 September 2010)
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Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study
Aya Kawasaki, Satoshi Ito, Hiroshi Furukawa, Taichi Hayashi, Daisuke Goto, Isao Matsumoto, Makio Kusaoi, Jun Ohashi, Robert R Graham, Kunio Matsuta, Timothy W Behrens, Shigeto Tohma, Yoshinari Takasaki, Hiroshi Hashimoto, Takayuki Sumida, Naoyuki Tsuchiya Arthritis Research & Therapy 2010, 12:R174 (17 September 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
TNIP1 is associated with increased risk of systemic lupus erythematosus (SLE) in both Asian and Caucasian populations, with a greater genetic contribution found in Japanese and Chinese populations.
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Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease
Stephen Eyre, Anne Hinks, John Bowes, Edward Flynn, Paul Martin, Anthony G Wilson, Ann W Morgan, Paul Emery, Sophia Steer, Lynne J Hocking, David M Reid, Pille Harrison, Paul Wordsworth, Yorkshire Early Arthritis (YEAR) Consortium, Biologics in RA Control (BIRAC) Consortium, Wendy Thomson, Jane Worthington, Anne Barton Arthritis Research & Therapy 2010, 12:R175 (20 September 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
The TAGAP (T-cell activation RhoGTPase activating protein) gene, previously associated with both type 1 diabetes and coeliac disease, is also associated with rheumatoid arthritis susceptibility.
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Effect of etanercept in polymyalgia rheumatica: a randomized controlled trial
Frederik Kreiner, Henrik Galbo Arthritis Research & Therapy 2010, 12:R176 (20 September 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Etanercept monotherapy decreases disease activity by 24% in patients with polymyalgia rheumatica (PMR), indicating that tumour necrosis factor-alpha plays only a minor role in the pathophysiology of PMR.
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Validity of the work productivity and activity impairment questionnaire - general health version in patients with rheumatoid arthritis
Wei Zhang, Nick Bansback, Annelies Boonen, Adam Young, Amitabh Singh, Aslam H Anis Arthritis Research & Therapy 2010, 12:R177 (22 September 2010)
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Intravenous administration of anti-vascular endothelial growth factor humanized monoclonal antibody bevacizumab improves articular cartilage repair
Toshihiro Nagai, Masato Sato, Toshiharu Kutsuna, Mami Kokubo, Goro Ebihara, Naoshi Ohta, Joji Mochida Arthritis Research & Therapy 2010, 12:R178 (24 September 2010)
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Editor’s summary
Anti-VEGF humanized monoclonal antibody bevacizumab improves articular cartilage repair in an osteochondral defect rabbit model, presenting a possible alternative to using cultured cells or artificial scaffolds.
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Validity of clinical associations of biomarkers in translational research studies: the case of systemic autoimmune diseases
Maria G Tektonidou, Michael M Ward Arthritis Research & Therapy 2010, 12:R179 (27 September 2010)
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Heritability patterns in hand osteoarthritis: the role of osteophytes
Mariko L Ishimori, Roy D Altman, Myles J Cohen, Jinrui Cui, Xiuqing Guo, Jerome I Rotter, Michael H Weisman Arthritis Research & Therapy 2010, 12:R180 (28 September 2010)
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Small artery elasticity is decreased in patients with systemic lupus erythematosus without increased intima media thickness
Hans LA Nienhuis, Karina de Leeuw, Johan Bijzet, Jasper J van Doormaal, Arie M van Roon, Andries J Smit, Reindert Graaff, Cees GM Kallenberg, Marc Bijl Arthritis Research & Therapy 2010, 12:R181 (28 September 2010)
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Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis
Yvonne H Sniekers, Harrie Weinans, Gerjo JVM van Osch, Johannes PTM van Leeuwen Arthritis Research & Therapy 2010, 12:R182 (5 October 2010)
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Editor’s summary
Combination of ovariectomy with a mild osteoarthritis trigger significantly decreases subchondral cortical thickness in a mouse model, demonstrating the significance of estrogen for articular cartilage and maintenance of healthy joints.
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Rheumatoid arthritis patients receive less frequent acute reperfusion and secondary prevention therapy after myocardial infarction compared with the general population
Sharon Van Doornum, Caroline Brand, Vijaya Sundararajan, Andrew E Ajani, Ian P Wicks Arthritis Research & Therapy 2010, 12:R183 (7 October 2010)
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Editor’s summary
Rheumatoid arthritis patients are less likely to receive acute reperfusion and secondary prevention therapy after myocardial infarction compared to the general population.
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Rheumatoid synovial fluid interleukin-17-producing CD4 T cells have abundant tumor necrosis factor-alpha co-expression, but little interleukin-22 and interleukin-23R expression
Leigh D Church, Andrew D Filer, Esther Hidalgo, Katherine A Howlett, Andrew MC Thomas, Stephen Rapecki, Dagmar Scheel-Toellner, Christopher D Buckley, Karim Raza Arthritis Research & Therapy 2010, 12:R184 (7 October 2010)
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Influence of comorbidity with depression on interdisciplinary therapy: outcomes in patients with chronic low back pain
Haili Wang, Carsten Ahrens, Winfried Rief, Marcus Schiltenwolf Arthritis Research & Therapy 2010, 12:R185 (11 October 2010)
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Influence of depression symptoms on serum tumor necrosis factor-α of patients with chronic low back pain
Haili Wang, Carsten Ahrens, Winfried Rief, Simone Gantz, Marcus Schiltenwolf, Wiltrud Richter Arthritis Research & Therapy 2010, 12:R186 (11 October 2010)
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Prediction model for knee osteoarthritis based on genetic and clinical information
Hiroshi Takahashi, Masahiro Nakajima, Kouichi Ozaki, Toshihiro Tanaka, Naoyuki Kamatani, Shiro Ikegawa Arthritis Research & Therapy 2010, 12:R187 (12 October 2010)
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CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis
Soo-Hyun Chung, Keisuke Seki, Byung-Il Choi, Keiko B Kimura, Akihiko Ito, Noriyuki Fujikado, Shinobu Saijo, Yoichiro Iwakura Arthritis Research & Therapy 2010, 12:R188 (12 October 2010)
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Editor’s summary
CXC chemokine 4 (CXCR4) expression contributes to the development of murine collagen-induced arthritis by recruiting activated T cells into inflammatory sites, highlighting CXCR4 as a potential therapeutic target for rheumatoid arthritis.
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Does moderate-to-high intensity Nordic walking improve functional capacity and pain in fibromyalgia? A prospective randomized controlled trial
Kaisa Mannerkorpi, Lena Nordeman, Åsa Cider, Gunilla Jonsson Arthritis Research & Therapy 2010, 12:R189 (13 October 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Nordic Walking is a feasible mode of exercise for women with fibromyalgia that can improve functional capacity and reduce the level of activity limitations without risking a pain flare.
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Adrenomedullin increases fibroblast-like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation
Marie-Dominique Ah Kioon, Carine Asensio, Hang-Korng Ea, Benjamin Uzan, Martine Cohen-Solal, Frédéric Lioté Arthritis Research & Therapy 2010, 12:R190 (14 October 2010)
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Disease-specific definitions of vitamin D deficiency need to be established in autoimmune and non-autoimmune chronic diseases: a retrospective comparison of three chronic diseases
Anna R Broder, Jonathan N Tobin, Chaim Putterman Arthritis Research & Therapy 2010, 12:R191 (14 October 2010)
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A phase 2 randomized, double-blind study of AMG 108, a fully human monoclonal antibody to IL-1R, in patients with rheumatoid arthritis
Mario H Cardiel, Paul P Tak, William Bensen, Francis X Burch, Sarka Forejtova, Janusz E Badurski, Tarundeep Kakkar, Terry Bevirt, Liyun Ni, Ellen McCroskery, Angelika Jahreis, Debra J Zack Arthritis Research & Therapy 2010, 12:R192 (15 October 2010)
Abstract | Full text | PDF | PubMed | F1000 Medicine | F1000 Biology
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Lifestyle factors and lumbar disc disease: results of a German multi-center case-control study (EPILIFT)
Barbara Schumann, Ulrich Bolm-Audorff, Annekatrin Bergmann, Rolf Ellegast, Gine Elsner, Joachim Grifka, Johannes Haerting, Matthias Jäger, Martina Michaelis, Andreas Seidler Arthritis Research & Therapy 2010, 12:R193 (18 October 2010)
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Autoantibodies to BRAF, a new family of autoantibodies associated with rheumatoid arthritis
Caroline Charpin, Marielle Martin, Nathalie Balandraud, Jean Roudier, Isabelle Auger Arthritis Research & Therapy 2010, 12:R194 (18 October 2010)
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Pomegranate extract inhibits the interleukin-1β-induced activation of MKK-3, p38α-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
Zafar Rasheed, Nahid Akhtar, Tariq M Haqqi Arthritis Research & Therapy 2010, 12:R195 (18 October 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Pomegranate extract inhibits activation of MKK3, a mediator of cartilage catabolism in osteoarthritis (OA), in a cellular model, suggesting that it could be developed into a treatment for OA and other degenerative diseases.
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Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis
Rita Cascão, Rita A Moura, Inês Perpétuo, Helena Canhão, Elsa Vieira-Sousa, Ana F Mourão, Ana M Rodrigues, Joaquim Polido-Pereira, Mário V Queiroz, Henrique S Rosário, Maria M Souto-Carneiro, Luis Graca, João E Fonseca Arthritis Research & Therapy 2010, 12:R196 (20 October 2010)
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Infliximab therapy increases body fat mass in early rheumatoid arthritis independently of changes in disease activity and levels of leptin and adiponectin: a randomised study over 21 months
Inga-Lill Engvall, Birgitta Tengstrand, Kerstin Brismar, Ingiäld Hafström Arthritis Research & Therapy 2010, 12:R197 (21 October 2010)
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Ibandronate increases cortical bone density in patients with systemic lupus erythematosus on long-term glucocorticoid
Edmund K Li, Tracy Y Zhu, Vivian Y Hung, Anthony W Kwok, Vivian W Lee, Kenneth K Lee, James F Griffith, Martin Li, Kong Chiu Wong, Ping Chung Leung, Ling Qin, Lai Shan Tam Arthritis Research & Therapy 2010, 12:R198 (22 October 2010)
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Urokinase-type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis models
Christine M De Nardo, Jason C Lenzo, Jarrad Pobjoy, John A Hamilton, Andrew D Cook Arthritis Research & Therapy 2010, 12:R199 (25 October 2010)
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Collagen-induced arthritis in common marmosets: a new nonhuman primate model for chronic arthritis
Michel PM Vierboom, Elia Breedveld, Ivanela Kondova, Bert A 't Hart Arthritis Research & Therapy 2010, 12:R200 (26 October 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis
Rana El-Bikai, Mélanie Welman, Yoran Margaron, Jean-François Côté, Luke Macqueen, Michael D Buschmann, Hassan Fahmi, Qin Shi, Karim Maghni, Julio C Fernandes, Mohamed Benderdour Arthritis Research & Therapy 2010, 12:R201 (26 October 2010)
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Comparison of 3T MR scanners in regional cartilage-thickness analysis in osteoarthritis: a cross-sectional multicenter, multivendor study
Sharon Balamoody, Tomos G Williams, John C Waterton, Michael Bowes, Richard Hodgson, Chris J Taylor, Charles E Hutchinson Arthritis Research & Therapy 2010, 12:R202 (28 October 2010)
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Correspondence |
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The influence of anti-cyclic citrullinated peptide on anticentromere antibody-positive rheumatoid arthritis patients
La-He Jearn, Think-You Kim Arthritis Research & Therapy 2010, 12:406 (29 October 2010)
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The influence of anti-cyclic citrullinated peptide on anticentromere antibody-positive rheumatoid arthritis patients: authors' response
Panayiotis G Vlachoyiannopoulos, Vasiliki-Kalliopi Bournia Arthritis Research & Therapy 2010, 12:407 (29 October 2010)
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