Table 3 |
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|
Frequencies of GR polymorphisms in RA patients vs. blood donor controls, adjusted for age and sex |
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|
Polymorphism |
RA Case, n (%) |
Blood donors Control, n (%) |
Unadjusted OR (95% CI) |
P-value |
Adjusted OR (95% CI) |
P-value |
|
|
||||||
|
ER22/23EK |
||||||
|
Non-carriers |
336 (91.3%) |
495 (93.0%) |
reference |
reference |
||
|
Carriers |
32 (8.7%)1 |
37 (7.0%)2 |
1.27 (0.78-2.08) |
0.335 |
1.54 (0.82-2.90) |
0.181 |
|
N363S |
||||||
|
Non-carriers |
352 (95.7%) |
493 (92.7%) |
reference |
reference |
||
|
Carriers |
16 (4.3%) |
39 (7.3%) |
0.58 (0.32-1.04) |
0.066 |
0.71 (0.34-1.50) |
0.380 |
|
BclI |
||||||
|
Non-carriers |
176 (47.8%) |
199 (37.4%) |
reference |
reference |
||
|
Carriers* |
192 (52.2%) |
333 (62.6%) |
0.65 (0.50-0.85) |
0.002 |
0.61 (0.43-0.86) |
0.005 |
|
Heterozygous carriers |
149 (40.5%) |
255 (47.9%) |
0.66 (0.50-0.88) |
0.004 |
0.63 (0.44-0.92) |
0.015 |
|
Homozygous carriers |
43 (11.7%) |
78 (14.7%) |
0.62 (0.41-0.95) |
0.028 |
0.53 (0.31-0.92) |
0.024 |
|
9β |
||||||
|
Non-carriers |
233 (63.3%) |
367 (69.0%) |
reference |
reference |
||
|
Carriers* |
135 (36.7%) |
165 (31.0%) |
1.29 (0.97-1.71) |
0.076 |
1.44 (1.001-2.07) |
0.049 |
|
Heterozygous carriers |
124 (33.7%) |
147 (27.6%) |
1.33 (0.995-1.78) |
0.054 |
1.52 (1.05-2.22) |
0.028 |
|
Homozygous carriers |
11 (3.0%) |
18 (3.4%) |
0.96 (0.45-2.04) |
0.992 |
0.85 (0.32-2.27) |
0.746 |
|
|
||||||
|
1 One homozygous carrier. 2 One homozygous carrier. * This includes hetero- and homozygous carriers. CI, confidence interval; GR, glucocorticoid receptor; OR, odds ratio; RA, rheumatoid arthritis. |
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|
van Oosten et al. Arthritis Research & Therapy 2010 12:R159 doi:10.1186/ar3118 |
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