Table 1

Serologic associations observed in SLE patients in the replication cohort, best fit model from logistic regression

Locus and Allele

Associated Antibody Profile

Ancestral Background

Odds Ratio (95% CI)

P-value

LRRC20 rs10762360 G

Anti-La

AA

2.40

(1.51 to 3.81)

1.6 × 10^-4

PPM1 H rs10784318 C

Anti-La

EA and HA joint

3.74

(1.88 to 7.47)

3.6 × 10^-5

LPAR1 rs10980684 T

Anti-Ro with Anti-Sm

AA and HA joint

2.22

(1.42 to 3.47)

1.2 × 10^-4

ANKS1A rs2820223 C

Anti-Ro with Anti-dsDNA

AA

3.14

(1.68 to 5.87)

3.5 × 10^-4

PTPRM rs17494870 C

-

-

-

-

EFNA5 rs26725 C

Anti-RNP

AA

1.73

(1.10 to 2.72)

0.018

VSIG2 rs11219769 T

Anti-RNP lacking Anti-Sm

EA and HA joint

3.99

(1.81 to 8.75)

2.1 × 10^-4

AA, African-American, EA, European-American, HA, Hispanic-American, 95% CI, 95% confidence interval; "joint" indicates that two or more ancestral backgrounds showed a similar tendency when analyzed separately with a non-significant difference observed between odds ratios, and that the indicated ancestral backgrounds were analyzed jointly using a fixed-effects model.

Kariuki et al. Arthritis Research & Therapy 2010 12:R151   doi:10.1186/ar3101