Research article
Gene expression profiling in circulating endothelial cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by iloprost infusion
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* Corresponding authors: Antonio Puccetti apuccetti@gmail.com - Claudio Lunardi claudio.lunardi@univr.it
- † Equal contributors
1 Section of Internal Medicine B, Department of Medicine, University of Verona, P.le LA Scuro, 10, 37134, Verona, Italy
2 Immunology Unit, Institute G. Gaslini, Largo G. Gaslini, 16147, Genova, Italy
3 Section of Histology, Department of Experimental Medicine, University of Genova, Via Marsano 10, 16132, Genova, Italy
4 Section of Hematology, Department of Medicine, University of Verona, P.le LA Scuro, 10, 37134, Verona, Italy
5 Section of Internal Medicine D, Department of Medicine, University of Verona, P.le LA Scuro, 10, 37134, Verona, Italy
Arthritis Research & Therapy 2010, 12:R131 doi:10.1186/ar3069
Published: 7 July 2010Additional files
Additional file 1:
Gene expression profile in healthy subjects. Raw intensity signal values obtained from the sample of healthy subjects.
Format: CEL Size: 5.1MB Download file
Additional file 2:
Gene expression profile in SSc patients with ulcers. Raw intensity signal values present in the sample obtained from SSc patients with ulcers.
Format: CEL Size: 5.1MB Download file
Additional file 3:
Modulated genes in circulating endothelial cells of patients with ulcers compared to normal controls. Fold change values obtained from the comparison between the expression levels of genes in circulating endothelial cells of patients with skin ulcers and those of normal controls.
Format: XLS Size: 3.6MB Download file
This file can be viewed with: Microsoft Excel Viewer
Additional file 4:
Gene expression profile in SSc patients without ulcers. Raw intensity signal values obtained from the sample of SSc patients without skin ulcers.
Format: CEL Size: 5.1MB Download file
Additional file 5:
Genes modulated in SSc patients without ulcers compared to healthy donors. Fold change values obtained from the comparison between the expression levels of genes in circulating endothelial cells of patients without ulcers and those of healthy donors.
Format: XLS Size: 3.1MB Download file
This file can be viewed with: Microsoft Excel Viewer
Additional file 6:
Gene expression profile in SSc patients with ulcers after treatment. Raw intensity signal values obtained from the sample of SSc patients with ulcers after treatment with Iloprost.
Format: CEL Size: 5.1MB Download file
Additional file 7:
Genes modulated by Iloprost treatment in patients with skin ulcers. Fold change values of modulated genes obtained from the comparison between the expression levels of genes in circulating endothelial cells of patients with skin ulcers after Iloprost treatment and those of the same patients before Iloprost treatment.
Format: XLS Size: 3.1MB Download file
This file can be viewed with: Microsoft Excel Viewer
Additional file 8:
Gene expression profile in SSc patients without ulcers after Iloprost treatment. Raw intensity signal values of the sample obtained from SSc patients without skin ulcers after treatment.
Format: CEL Size: 5.1MB Download file
Additional file 9:
Genes modulated by Iloprost treatment in patients without skin ulcers. Fold change values obtained from the comparison between the expression levels of genes in circulating endothelial cells of patients without skin ulcers after Iloprost treatment and those of the same patients before Iloprost treatment.
Format: XLS Size: 3.1MB Download file
This file can be viewed with: Microsoft Excel Viewer