Table 1 |
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|
Knee joint histology, tibial cartilage material property, and trabecular bone osteoarthritis outcomes |
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|
Parameter |
Control |
LG |
HG |
Diet (P value) |
Diet × percentage body fat (P value) |
|
|
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|
Knee modified Mankin score |
18.2 ± 1.5 |
15.8 ± 2.5 |
25.1 ± 1.5* |
0.17 |
0.003 |
|
Cartilage degeneration |
4.4 ± 0.7 |
5.1 ± 0.9 |
6.7 ± 0.9 |
0.11 |
0.47 |
|
Safranin-O loss |
7.7 ± 1.0 |
3.8 ± 0.3* |
11.7 ± 0.8*# |
0.66 |
<0.001 |
|
Tidemark duplication |
0.22 ± 0.11 |
0.16 ± 0.10 |
0.13 ± 0.13 |
0.60 |
0.29 |
|
Chondrocyte cloning |
0.67 ± 0.22 |
0.42 ± 0.16 |
1.1 ± 0.3 |
0.70 |
0.14 |
|
Hypertrophic chondrocytes |
1.8 ± 0.3 |
1.3 ± 0.7 |
2.1 ± 0.4 |
0.88 |
0.18 |
|
Fibrocartilage |
0.04 ± 0.04 |
0.33 ± 0.33 |
0 ± 0 |
0.48 |
0.34 |
|
Relative subchondral bone thickness |
3.4 ± 0.3 |
4.7 ± 0.5 |
3.5 ± 0.7 |
0.26 |
0.31 |
|
Aggregate modulus (HA) |
1.49 ± 0.18 |
2.18 ± 0.03 |
1.74 ± 0.20 |
0.003 |
0.10 |
|
Permeability (× 10-16, m4/N-s) |
2.38 ± 0.67 |
1.90 ± 0.32 |
1.80 ± 0.60 |
0.48 |
0.77 |
|
Relative tibial epiphysis trabecular bone volume |
0.43 ± 0.02 |
0.51 ± 0.07 |
0.40 ± 0.03 |
0.56 |
0.72 |
|
|
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|
Statistical differences among control, low gainer (LG), and high gainer (HG) values were determined with a hierarchical analysis of variance. Overall diet and diet × percentage body fat effects were analyzed by analysis of covariance. *P < 0.05 compared with control values. #P < 0.05 for HG versus LG values. P values less than 0.05 shown in bold. |
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|
Griffin et al. Arthritis Research & Therapy 2010 12:R130 doi:10.1186/ar3068 |
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