Bcl-xL affects the development of functional CD4 Tregs
1 Department of Immunology, The Weizmann Institute of Science, 240 Hertzl Street, Rehovot 76100, Israel
2 Department of Internal Medicine B, The Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel. Published: 23 July 2010
Arthritis Research & Therapy 2010, 12:405 doi:10.1186/ar3076
See related research by Haque et al., http://arthritis-research.com/content/12/2/R66Published: 23 July 2010
First paragraph (this article has no abstract)
We read with great interest the article by Haque and colleagues  in a recent issue of Arthritis Research & Therapy. They hypothesized that co-transduction of CD4+ T cells with both forkhead box P3 transcription factor (FoxP3) and Bcl-xL will generate highly reactive regulatory T cells (Tregs) that can be used to prevent auto immune disease. The authors showed that the accumulation, persistence, and efficient function of Tregs were attributable to the expression of Bcl-xL in CD4 Tregs.