Figure 1.

Schematic outline of a possible treatment algorithm for rheumatoid arthritis medication. The regimen can be modified by either changing the medications and/or their combinations on the same level or by switching the level and continuing with the next sequential step according to the patient's situation and disease status. Thus, the graphical illustration does not claim exclusive appropriateness, and the treating physician has to consider individual patient-and situation-adapted medication. ABC, abatacept; ANR, anakinra; CsA, cyclosporin A; HQ, hydroxychloroquine; LEF, leflunomide; MTX, methotrexate; RIX, rituximab; SSZ, sulfasalazine; TOZ, tocilizumab.