Osteoarthritis and a high-fat diet: the full 'OA syndrome' in a small animal model
Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
Current address: Nijmegen Centre for Molecular Life Sciences (NCMLS), Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands
Arthritis Research & Therapy 2010, 12:130 doi:10.1186/ar3082
See related research by Griffin et al., http://arthritis-research.com/content/12/4/R130Published: 28 July 2010
Obesity is one of the main risk factors for osteoarthritis (OA) and due to the global rise in obesity this will increasingly contribute to OA development. The article of Griffin and co-workers in this issue of Arthritis Research and Therapy shows that a high-fat diet leads to obesity and OA in the studied animals and that this is related to alterations in locomotor function. Furthermore, a high-fat diet leads to pain sensitization and depression/anxiety-like behavior unrelated to structural OA changes in the knee. Their findings demonstrate that the majority of features of the human 'OA syndrome' can be reproduced in a small animal model.