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Volume 12 Issue 4
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Comment |
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Remission makes its way to rheumatology
Tuulikki Sokka, Heidi Mäkinen Arthritis Research & Therapy 2010, 12:129 (14 July 2010)
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Osteoarthritis and a high-fat diet: the full 'OA syndrome' in a small animal model
Peter M van der Kraan Arthritis Research & Therapy 2010, 12:130 (28 July 2010)
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Exercise-induced changes in interleukin-10 in patients with knee osteoarthritis: new perspectives?
Willem F Lems, Debby den Uyl Arthritis Research & Therapy 2010, 12:131 (29 July 2010)
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Efficacy assessed in follow-ups of clinical trials: methodological conundrum
Robert BM Landewé Arthritis Research & Therapy 2010, 12:132 (30 July 2010)
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A personal journey from the joint to the heart
Bruce N Cronstein Arthritis Research & Therapy 2010, 12:134 (13 August 2010)
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Could the expression of CD86 and FcγRIIB on B cells be functionally related and involved in driving rheumatoid arthritis?
Claudia Mauri, Elizabeth C Jury Arthritis Research & Therapy 2010, 12:133 (13 August 2010)
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Mesenchymal stem cells in arthritis: role of bone marrow microenvironment
Christian Jorgensen Arthritis Research & Therapy 2010, 12:135 (23 August 2010)
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Arthritis Research & Therapy evolves: online only from 2011
Iain Hrynaszkiewicz, Peter E Lipsky, Ravinder N Maini Arthritis Research & Therapy 2010, 12:137 (25 August 2010)
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A new tool for detection of type I interferon activation in systemic lupus erythematosus
Kyriakos A Kirou, George D Kalliolias Arthritis Research & Therapy 2010, 12:138 (26 August 2010)
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Review |
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New developments in osteoarthritis. Sex differences in magnetic resonance imaging-based biomarkers and in those of joint metabolism
Mehrnaz Maleki-Fischbach, Joanne M Jordan Arthritis Research & Therapy 2010, 12:212 (30 July 2010)
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Interstitial lung disease in connective tissue diseases: evolving concepts of pathogenesis and management
Flavia V Castelino, John Varga Arthritis Research & Therapy 2010, 12:213 (23 August 2010)
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Rationale of using different biological therapies in rheumatoid arthritis
Matthias Geyer, Ulf Müller-Ladner Arthritis Research & Therapy 2010, 12:214 (24 August 2010)
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New developments in osteoarthritis. Prevention of injury-related knee osteoarthritis: opportunities for the primary and secondary prevention of knee osteoarthritis
Charles R Ratzlaff, Matthew H Liang Arthritis Research & Therapy 2010, 12:215 (31 August 2010)
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Research |
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Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial
Ida C Helmark, Ulla R Mikkelsen, Jens Børglum, Anders Rothe, Marie CH Petersen, Ove Andersen, Henning Langberg, Michael Kjaer Arthritis Research & Therapy 2010, 12:R126 (1 July 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
A single bout of mechanical joint loading increases intraarticular and peri-synovial concentrations of interleukin-10 in females with knee osteoarthritis, suggesting exercise enhances the chondroprotective anti-inflammatory cytokine response.
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Curcumin mediated suppression of nuclear factor-κB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment
Constanze Buhrmann, Ali Mobasheri, Ulrike Matis, Mehdi Shakibaei Arthritis Research & Therapy 2010, 12:R127 (1 July 2010)
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Editor’s summary
Curcumin, a naturally-occurring nuclear factor-KB inhibitor, protects mesenchymal stem cells (MSCs) from the harmful effects of pro-inflammatory cytokines, thereby establishing a suitable microenvironment for MSCs to undergo chondrogenesis.
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Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis
Nobuyo Higashi-Kuwata, Masatoshi Jinnin, Takamitsu Makino, Satoshi Fukushima, Yuji Inoue, Faith C Muchemwa, Yuji Yonemura, Yoshihiro Komohara, Motohiro Takeya, Hiroaki Mitsuya, Hironobu Ihn Arthritis Research & Therapy 2010, 12:R128 (5 July 2010)
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Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis
Chun K Wong, Da P Chen, Lai S Tam, Edmund K Li, Yi B Yin, Christopher WK Lam Arthritis Research & Therapy 2010, 12:R129 (6 July 2010)
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Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice
Timothy M Griffin, Beverley Fermor, Janet L Huebner, Virginia B Kraus, Ramona M Rodriguiz, William C Wetsel, Li Cao, Lori A Setton, Farshid Guilak Arthritis Research & Therapy 2010, 12:R130 (6 July 2010)
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Gene expression profiling in circulating endothelial cells from systemic sclerosis patients shows an altered control of apoptosis and angiogenesis that is modified by iloprost infusion
Elisa Tinazzi, Marzia Dolcino, Antonio Puccetti, Antonella Rigo, Ruggero Beri, Maria Valenti, Roberto Corrocher, Claudio Lunardi Arthritis Research & Therapy 2010, 12:R131 (7 July 2010)
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Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins
Katleen Van Steendam, Kelly Tilleman, Marlies De Ceuleneer, Filip De Keyser, Dirk Elewaut, Dieter Deforce Arthritis Research & Therapy 2010, 12:R132 (7 July 2010)
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Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis
Tomoko Kawabata, Keiichiro Nishida, Koji Takasugi, Hiroko Ogawa, Kenei Sada, Yasutaka Kadota, Junko Inagaki, Satoshi Hirohata, Yoshifumi Ninomiya, Hirofumi Makino Arthritis Research & Therapy 2010, 12:R133 (7 July 2010)
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Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate
Nicolas Fayed, Javier Garcia-Campayo, Rosa Magallón, Helena Andrés-Bergareche, Juan V Luciano, Eva Andres, Julián Beltrán Arthritis Research & Therapy 2010, 12:R134 (7 July 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Innate immunity triggers IL-32 expression by fibroblast-like synoviocytes in rheumatoid arthritis
Ghada Alsaleh, Laetitia Sparsa, Emmanuel Chatelus, Mathieu Ehlinger, Jacques-Eric Gottenberg, Dominique Wachsmann, Jean Sibilia Arthritis Research & Therapy 2010, 12:R135 (8 July 2010)
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Editor’s summary
Interleukin-32 expression by fibroblast-like synoviocytes is tightly regulated by innate immunity in rheumatoid arthritis (RA), highlighting it as a potential therapeutic target in RA.
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Modulation of collagen-induced arthritis by adenovirus-mediated intra-articular expression of modified collagen type II
Bo Tang, David L Cullins, Jing Zhou, Janice A Zawaski, Hyelee Park, David D Brand, Karen A Hasty, M Waleed Gaber, John M Stuart, Andrew H Kang, Linda K Myers Arthritis Research & Therapy 2010, 12:R136 (8 July 2010)
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Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus
Ou Jin, Sushma Kavikondala, Mo-Yin Mok, Lingyun Sun, Jieruo Gu, Rong Fu, Albert Chan, Joseph Yeung, Yingjie Nie, Chak-Sing Lau Arthritis Research & Therapy 2010, 12:R137 (9 July 2010)
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Editor’s summary
Plasmacytoid dendritic cells are less capable of inducing regulatory T cell differentiation and lack toll like receptor-9 recruitment in systemic lupus erythematosus (SLE) patients compared with controls, suggesting a potential pathologic role in SLE.
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Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocytes
Valentina Calamia, Cristina Ruiz-Romero, Beatriz Rocha, Patricia Fernández-Puente, Jesús Mateos, Eulàlia Montell, Josep Vergés, Francisco J Blanco Arthritis Research & Therapy 2010, 12:R138 (13 July 2010)
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Does an increase in body mass index over 10 years affect knee structure in a population-based cohort study of adult women?
Sharon L Brennan, Flavia M Cicuttini, Julie A Pasco, Margaret J Henry, Yuanyuan Wang, Mark A Kotowicz, Geoff C Nicholson, Anita E Wluka Arthritis Research & Therapy 2010, 12:R139 (13 July 2010)
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Editor’s summary
Female weight gain during early adulthood is associated with increased prevalence of bone marrow lesions and detrimental effects on cartilage, which may increase the risk of developing knee osteoarthritis.
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Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis
Michael K Boettger, Johannes Leuchtweis, Diana Kümmel, Mieczyslaw Gajda, Rolf Bräuer, Hans-Georg Schaible Arthritis Research & Therapy 2010, 12:R140 (13 July 2010)
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Editor’s summary
Locally administered soluble glycoprotein 130 attenuates arthritic pain modulated by interleukin-6 signalling pathways and is effective in preventing joint destruction in an experimental model of arthritis.
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Effect of duloxetine in patients with fibromyalgia: tiredness subgroups
Laurence A Bradley, Robert Bennett, Irwin J Russell, Madelaine M Wohlreich, Amy S Chappell, Fujun Wang, Deborah N D'Souza, Harvey Moldofsky Arthritis Research & Therapy 2010, 12:R141 (14 July 2010)
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Editor’s summary
Duloxetine efficacy on measures of pain and functional ability does not vary according to patients' fatigue levels, finds an analysis of four randomised controlled trials.
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Maintenance of cytomegalovirus-specific CD4pos T-cell response in rheumatoid arthritis patients receiving anti-tumor necrosis factor treatments
Jean-Luc Davignon, Jean-Frédéric Boyer, Bénédicte Jamard, Delphine Nigon, Arnaud Constantin, Alain Cantagrel Arthritis Research & Therapy 2010, 12:R142 (15 July 2010)
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Rare incidence of methotrexate-specific lesions in liver biopsy of patients with arthritis and elevated liver enzymes
Emilie Quintin, Jean-Yves Scoazec, Hubert Marotte, Pierre Miossec Arthritis Research & Therapy 2010, 12:R143 (16 July 2010)
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The delivery of evidence-based preventive care for older Americans with arthritis
Jeffrey R Curtis, Tarun Arora, Pongthorn Narongroeknawin, Allison Taylor, Clifton O Bingham, Jack Cush, Kenneth G Saag, Monika Safford, Elizabeth Delzell Arthritis Research & Therapy 2010, 12:R144 (16 July 2010)
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Risk factors for total joint arthroplasty infection in patients receiving tumor necrosis factor α-blockers: a case-control study
Mélanie Gilson, Laure Gossec, Xavier Mariette, Dalenda Gherissi, Marie-Hélène Guyot, Jean-Marie Berthelot, Daniel Wendling, Christian Michelet, Pierre Dellamonica, Florence Tubach, Maxime Dougados, Dominique Salmon Arthritis Research & Therapy 2010, 12:R145 (16 July 2010)
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TAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus
Chang-Hee Suh, Brendan Hilliard, Sophia Li, Joan T Merrill, Philip L Cohen Arthritis Research & Therapy 2010, 12:R146 (16 July 2010)
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Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis
Rebecca Anderson, Angels Franch, Margarida Castell, Francisco J Perez-Cano, Rolf Bräuer, Dirk Pohlers, Mieczyslaw Gajda, Alexandros P Siskos, Theodora Katsila, Constantin Tamvakopoulos, Una Rauchhaus, Steffen Panzner, Raimund W Kinne Arthritis Research & Therapy 2010, 12:R147 (19 July 2010)
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Synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-α blockade in the knee joint
Ugo Fiocco, Paolo Sfriso, Francesca Oliviero, Pascale Roux-Lombard, Elena Scagliori, Luisella Cozzi, Francesca Lunardi, Fiorella Calabrese, Maristella Vezzù, Serena Dainese, Beatrice Molena, Anna Scanu, Roberto Nardacchione, Leopoldo Rubaltelli, Jean Michel Dayer, Leonardo Punzi Arthritis Research & Therapy 2010, 12:R148 (19 July 2010)
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Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis
Sindhu T Mohanty, Lucksy Kottam, Alessandra Gambardella, Martin J Nicklin, Les Coulton, David Hughes, Anthony G Wilson, Peter I Croucher, Ilaria Bellantuono Arthritis Research & Therapy 2010, 12:R149 (22 July 2010)
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Increased expression of costimulatory markers CD134 and CD80 on interleukin-17 producing T cells in patients with systemic lupus erythematosus
Sebastian Dolff, Daniel Quandt, Benjamin Wilde, Thorsten Feldkamp, Fan Hua, Xin Cai, Christof Specker, Andreas Kribben, Cees GM Kallenberg, Oliver Witzke Arthritis Research & Therapy 2010, 12:R150 (23 July 2010)
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Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus
Silvia N Kariuki, Beverly S Franek, Akaash A Kumar, Jasmine Arrington, Rachel A Mikolaitis, Tammy O Utset, Meenakshi Jolly, Mary K Crow, Andrew D Skol, Timothy B Niewold Arthritis Research & Therapy 2010, 12:R151 (26 July 2010)
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Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
Miriam Bellido, Laura Lugo, Jorge A Roman-Blas, Santos Castañeda, Jose R Caeiro, Sonia Dapia, Emilio Calvo, Raquel Largo, Gabriel Herrero-Beaumont Arthritis Research & Therapy 2010, 12:R152 (2 August 2010)
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Prevalence and risk factors of vertebral compression fractures in female SLE patients
Katarina Almehed, Szabolcs Hetényi, Claes Ohlsson, Hans Carlsten, Helena Forsblad-d'Elia Arthritis Research & Therapy 2010, 12:R153 (2 August 2010)
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Risk of osteoporotic fracture in a large population-based cohort of patients with rheumatoid arthritis
Seo Young Kim, Sebastian Schneeweiss, Jun Liu, Gregory W Daniel, Chun-Lan Chang, Katie Garneau, Daniel H Solomon Arthritis Research & Therapy 2010, 12:R154 (3 August 2010)
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Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor β-chain
Patrick Merky, Tsvetelina Batsalova, Robert Bockermann, Balik Dzhambazov, Bettina Sehnert, Harald Burkhardt, Johan Bäcklund Arthritis Research & Therapy 2010, 12:R155 (3 August 2010)
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Bone events and evolution of biologic markers in Gaucher disease before and during treatment
Jérôme Stirnemann, Nadia Belmatoug, Corine Vincent, Olivier Fain, Bruno Fantin, France Mentré Arthritis Research & Therapy 2010, 12:R156 (9 August 2010)
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Comparison of laser Doppler imaging, fingertip lacticemy test, and nailfold capillaroscopy for assessment of digital microcirculation in systemic sclerosis
Marcelo JU Correa, Luis EC Andrade, Cristiane Kayser Arthritis Research & Therapy 2010, 12:R157 (10 August 2010)
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Atherosclerosis in early rheumatoid arthritis: very early endothelial activation and rapid progression of intima media thickness
Anna Södergren, Kjell Karp, Kurt Boman, Catharina Eriksson, Elisabet Lundström, Torgny Smedby, Lisbet Söderlund, Solbritt Rantapää-Dahlqvist, Solveig Wållberg-Jonsson Arthritis Research & Therapy 2010, 12:R158 (16 August 2010)
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Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritis
Manon JM van Oosten, Radboud JEM Dolhain, Jan W Koper, Elisabeth FC van Rossum, Marieke Emonts, Khik H Han, Jacques MGW Wouters, Johanne MW Hazes, Steven WJ Lamberts, Richard A Feelders Arthritis Research & Therapy 2010, 12:R159 (21 August 2010)
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Editor’s summary
Glucocorticoid receptor gene polymorphisms ER22/23EK and 9beta are associated with an enhanced predisposition to develop rheumatoid arthritis and suggest a role for constitutionally determined glucocorticoid sensitivity in auto-immunity development.
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A multiparameter approach to monitor disease activity in collagen-induced arthritis
Sylvie Seeuws, Peggy Jacques, Jens Van Praet, Michael Drennan, Julie Coudenys, Tine Decruy, Ellen Deschepper, Lien Lepescheux, Philippe Pujuguet, Line Oste, Nick Vandeghinste, Reginald Brys, Gust Verbruggen, Dirk Elewaut Arthritis Research & Therapy 2010, 12:R160 (23 August 2010)
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Monocytes/macrophages express chemokine receptor CCR9 in rheumatoid arthritis and CCL25 stimulates their differentiation
Caroline Schmutz, Alison Cartwright, Helen Williams, Oliver Haworth, John HH Williams, Andrew Filer, Mike Salmon, Christopher D Buckley, Jim Middleton Arthritis Research & Therapy 2010, 12:R161 (25 August 2010)
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Relationship between patient-reported disease severity in osteoarthritis and self-reported pain, function and work productivity
Alesia B Sadosky, Andrew G Bushmakin, Joseph C Cappelleri, David R Lionberger Arthritis Research & Therapy 2010, 12:R162 (25 August 2010)
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The effect of risedronate on osteogenic lineage is mediated by cyclooxygenase-2 gene upregulation
Maria Teresa Valenti, Sandro Giannini, Luca Donatelli, Mirko Zanatta, Francesco Bertoldo, Stefania Sella, Maria Teresa Vilei, Elena Ossi, Giuseppe Realdi, Vincenzo Lo Cascio, Luca Dalle Carbonare Arthritis Research & Therapy 2010, 12:R163 (25 August 2010)
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Circulating mediators of bone remodeling in psoriatic arthritis: implications for disordered osteoclastogenesis and bone erosion
Nicola Dalbeth, Bregina Pool, Timothy Smith, Karen E Callon, Maria Lobo, William J Taylor, Peter B Jones, Jillian Cornish, Fiona M McQueen Arthritis Research & Therapy 2010, 12:R164 (26 August 2010)
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High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes
Isabel García-Arnandis, Maria Isabel Guillén, Francisco Gomar, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Maria José Alcaraz Arthritis Research & Therapy 2010, 12:R165 (27 August 2010)
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Correspondence |
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Bcl-xL affects the development of functional CD4 Tregs
Amir Sharabi, Edna Mozes Arthritis Research & Therapy 2010, 12:405 (23 July 2010)
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