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Open Access Research article

Time to achieve remission determines time to be in remission

Lydia G Schipper1*, Jaap Fransen1, Alfons A den Broeder2 and Piet LCM Van Riel1

Author affiliations

1 Department of Rheumatology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen, 6500 HB, The Netherlands

2 Department of Rheumatology, Sint Maartenskliniek Nijmegen, Hengstdal 3, Nijmegen, 6522 JV, The Netherlands

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Citation and License

Arthritis Research & Therapy 2010, 12:R97  doi:10.1186/ar3027

Published: 20 May 2010

Abstract

Introduction

Though remission is currently a treatment goal in patients with rheumatoid arthritis (RA), the number of patients who achieve and sustain remission in daily practice is still small. It is suggested that early remission will be associated with sustainability of remission. The aim was to study the association between time-to-remission and sustainability of remission in a cohort of early RA patients treated according to daily practice.

Methods

For this study, three-year follow-up data were used from the Nijmegen RA Inception Cohort of patients included between 1985 and 2005 (N = 753). Patients were included upon diagnosis (ACR criteria), were systematically evaluated at three-monthly visits and treated according to daily practice. Remission was defined according to the Disease Activity Score (DAS) <1.6 and the ACR remission criteria. Remission of at least 6 months duration was regarded as sustained remission. Predictors for time-to-remission were identified by Cox-regression analyses. The relation between time-to-remission and sustained remission was analyzed using longitudinal binary regression.

Results

N = 398 (52%) patients achieved remission with a median time-to-remission of 12 months. Male gender, younger age and low DAS at baseline were predictive to reach remission rapidly. There were n = 142 (36%) patients experiencing sustained remission, which was determined by a shorter time-to-remission only. The relationship between time-to-remission and sustained remission was described by a significant odds ratio (1.11) (1.10 to 1.12-95% CI) that was constant over the whole period 1985 to 2005. Results obtained with the ACR remission criteria were similar.

Conclusions

A shorter time-to-remission is related to sustainability of remission, supporting striving for early remission in patients with RA.