Decreased auto-immune symptoms presented in mice treated with L-4F or combination treatment. ELISA assays on serum from randomly selected female apoE-/-Fas-/- mice at Week 35 or 36 showed: (a) comparable total serum IgG antibody levels among the different groups, suggesting an absence of general immune suppression, significantly reduced levels of (b) IgG anti-dsDNA and (c) IgG anti-cardiolipin in L-4F-treated mice, and (d) significantly lower IgG anti-PGPC and IgG anti-POVPC in mice treated with L-4F in the absence/presence of pravastatin. Pravastatin alone did not have any significant effect on IgG anti-dsDNA or IgG anti-oxPL levels. (e) In addition, lymph nodes from L-4F or L-4F plus pravastatin-treated mice were significantly smaller compared to control mice. Each symbol represents an individual mouse and the horizontal line represents the mean value. P-values < 0.05 were considered significant. AU, arbitrary units.
Woo et al. Arthritis Research & Therapy 2010 12:R93 doi:10.1186/ar3020