Open Access Research article

Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis

Jennifer MP Woo1, Zhuofeng Lin1, Mohamad Navab2, Casey Van Dyck1, Yvette Trejo-Lopez1, Krystal MT Woo1, Hongyun Li1, Lawrence W Castellani3, Xuping Wang3, Noriko Iikuni1, Ornella J Rullo4, Hui Wu1, Antonio La Cava1, Alan M Fogelman5, Aldons J Lusis2 and Betty P Tsao1*

Author Affiliations

1 Department of Medicine-Rheumatology, David Geffen School of Medicine, University of California, 1000 Veteran Avenue, Los Angeles, CA 90095, USA

2 Department of Medicine-Cardiology, David Geffen School of Medicine, University of California, 1000 Veteran Avenue, Los Angeles, CA 90095, USA

3 Department of Medicine, Department of Microbiology, Immunology, and Molecular Genetics, Department of Human Genetics, David Geffen School of Medicine, University of California, 1000 Veteran Avenue, Los Angeles, CA 90095, USA

4 Department of Pediatrics-Rheumatology, David Geffen School of Medicine, University of California, 1000 Veteran Avenue, Los Angeles, CA 90095, USA

5 Department of Medicine, David Geffen School of Medicine, University of California, 1000 Veteran Avenue, Los Angeles, CA 90095, USA

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Arthritis Research & Therapy 2010, 12:R93  doi:10.1186/ar3020


See related editorial by Mendez-Fernandez and Major, http://arthritis-research.com/content/12/5/139

Published: 18 May 2010

Additional files

Additional file 1:

Supplemental table S1. Plasma samples from randomly selected mice were analyzed for 69 chemokines and cytokines using Luminex-base beadarray (RodentMap version 1.6; Rules Based Medicine, Inc.). *: Antigen not present at detectable levels.

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Additional file 2:

Supplemental figure S1. Movat staining of lesions of the aortic root did not show any statistically significant differences in local plaque environment of the aortic root between any of the treatment groups and the vehicle controls. (Elastic fibers-black, ground substance-blue, muscle-red, collagen-yellow, and fibrinoid and fibrin-intense red). Bar = 1 mm.

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