Additional file 1.
Inhibition of the enzyme activity by an ACE2 inhibitor. By preincubation with DX600 for 30 minutes, the enzyme activity was almost completely blocked (P < 0.01). H, healthy volunteer; P, patients with vasculopathy; CP, control patients without vasculopathy. The activity was also blocked by the addition of ethylenediamine tetraacetic acid (EDTA) (data not shown), indicating that the activity would depend on the presence of zinc ion.
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Takahashi et al. Arthritis Research & Therapy 2010 12:R85 doi:10.1186/ar3012