Table 1

Genes, that are differentially expressed during cell culture

Gene group

Regulated genes

RA-1

RA-2

RA-3

RA-4


Cytokines/-receptors

TNF receptor 1

3

5-8

5

3-8

MCSF I receptor precursor

6,8

6-8

2

5-8

epidermal growth factor receptor 1

3,4

-

6-8

4-8

insulin-like growth factor I receptor

>5

3,7

7-8

5,6,8

Adhesion

ILK

>5

2

2,6

↑↓

4-8

Apoptosis

Fas-activated serine/threonine kinase

cytotoxic TRAIL receptor 2 (DR 5)

4-8

7-8

6

6-8

5-8

2

7-8

8

Proliferation

tumor suppressor LUCA1

6-8

7-8

7-8

6,8

p33ING1

4-8

6-8

3-8

3-8

p53 cellular tumor antigen

4-8

6,8

3,7

7-8

cyclin-dependent kinase inhibitor 1C

6-8

2

4-8

-

ski oncogene

7-8

4

6,7

6,8

Proliferation/Signaling

shb proto-oncogene

4-8

7-8

-

2

Signaling

notch2

5-8

6

5,6,8

5

jun-B

7-8

4,5,7,8

5-8

4,7

frizzled

7-8

8

2

8

FRA2

3-8

7-8

5-7

2

NOTCH1 precursor

5-8

5

4,5

7-8

Others

semaphorin 1

7-8

-

4-8

3,4

glycogen synthase kinase 3 alpha

6-8

6

5-8

3-8

thymosin beta-10

5,6,8

4,6,7

7-8

5-8

ezrin; cytovillin 2; VIL2

7-8

4-8

4

5


Exemplary gene groups and genes and their regulations are shown. Only genes, that reached the signal threshold and the statistical significance level after Bonferroni-correction as described in methods were regarded as differentially expressed (P < 0.00025).

FRA2: fos-rrelated antigen 2; ILK: integrin-linked kinase; MCSF: macrophage colony-stimulating factor; RA: rheumatoid arthritis; TRAIL: tumor necrosis factor related apoptosis inducing ligand; VIL2: villin 2.

Neumann et al. Arthritis Research & Therapy 2010 12:R83   doi:10.1186/ar3010

Open Data