Table 1

Genes, that are differentially expressed during cell culture

Gene group

Regulated genes

RA-1

RA-2

RA-3

RA-4

Cytokines/-receptors

TNF receptor 1

3

↓

5-8

↑

5

↑

3-8

↑

MCSF I receptor precursor

6,8

↑

6-8

↓

2

↓

5-8

↓

epidermal growth factor receptor 1

3,4

↑

-

6-8

↑

4-8

↑

insulin-like growth factor I receptor

>5

↑

3,7

↑

7-8

↑

5,6,8

↑

Adhesion

ILK

>5

↓

2

↑

2,6

↑↓

4-8

↓

Apoptosis

Fas-activated serine/threonine kinase

cytotoxic TRAIL receptor 2 (DR 5)

4-8

↑

7-8

↑

6

↑

6-8

↑

5-8

↑

2

↓

7-8

↓

8

↑

Proliferation

tumor suppressor LUCA1

6-8

↑

7-8

↑

7-8

↑

6,8

↑

p33ING1

4-8

↑

6-8

↑

3-8

↑

3-8

↑

p53 cellular tumor antigen

4-8

↑

6,8

↑

3,7

↑

7-8

↑

cyclin-dependent kinase inhibitor 1C

6-8

↑

2

↑

4-8

↑

-

ski oncogene

7-8

↑

4

↑

6,7

↑

6,8

↑

Proliferation/Signaling

shb proto-oncogene

4-8

↓

7-8

↓

-

2

↓

Signaling

notch2

5-8

↑

6

↑

5,6,8

↑

5

↑

jun-B

7-8

↑

4,5,7,8

↑

5-8

↑

4,7

↑

frizzled

7-8

↑

8

↑

2

↑

8

↓

FRA2

3-8

↓

7-8

↓

5-7

↓

2

↑

NOTCH1 precursor

5-8

↑

5

↑

4,5

↑

7-8

↑

Others

semaphorin 1

7-8

↑

-

4-8

↓

3,4

↑

glycogen synthase kinase 3 alpha

6-8

↑

6

↑

5-8

↑

3-8

↑

thymosin beta-10

5,6,8

↓

4,6,7

↓

7-8

↑

5-8

↑

ezrin; cytovillin 2; VIL2

7-8

↓

4-8

↓

4

↑

5

↓

Exemplary gene groups and genes and their regulations are shown. Only genes, that reached the signal threshold and the statistical significance level after Bonferroni-correction as described in methods were regarded as differentially expressed (P < 0.00025).

FRA2: fos-rrelated antigen 2; ILK: integrin-linked kinase; MCSF: macrophage colony-stimulating factor; RA: rheumatoid arthritis; TRAIL: tumor necrosis factor related apoptosis inducing ligand; VIL2: villin 2.

Neumann et al. Arthritis Research & Therapy 2010 12:R83   doi:10.1186/ar3010