Changes in gene expression. Results are presented for one rheumatoid arthritis (RA) patient using an Atlas Human Cancer cDNA Expression Array for direct comparison of the relative intensities of the compared passages, showing strong variations at higher passages in this example. (a to g) Passage 1 was compared with higher passages. Examples of two genes are presented. In red: Expression of c-myc. In blue: expression of p33ING1 during culture of the exemplary RA synovial fibroblasts (SF) population. (h to l) In addition, higher passages are compared with each other showing the differential expression pattern between higher passages.
Neumann et al. Arthritis Research & Therapy 2010 12:R83 doi:10.1186/ar3010