Dose-response effect of NT and CT telopeptides. Constructs were cultured with NT (0.05 to 50 μM) or CT (0.05 to 50 μM) peptides under free-swelling conditions in the presence or absence of 1 mM 1400 W for 48 hours: (a) TNFα release and (b) IL-1β (n = 6). A scrambled form of the NT (SN) and CT (SC) peptide were used as negative controls (both at 50 μM). An NH2-FN-f (1 μM) was used as a positive control. (*) indicates significant comparisons for 0 vs fragment; (+) indicates significant comparisons for fragment vs fragment + 1400 W (n = 6).
Chowdhury et al. Arthritis Research & Therapy 2010 12:R82 doi:10.1186/ar3009