Table 5

Sensitivity analysis for the effect size on pain at post treatment

Outcome title

Number of study arms

Number of patients on aerobic exercise

Effect sizea

Test for overall effect, P value

Heterogeneity, I2; τ2 (%)


Adequate sequence generation

Adequate

11

251

-0.20 (-0.38, -0.01)

0.04

0; 0

Unclear or nonadequate

18

348

-0.39 (-0.61, -0.18)

0.0004

39; 0.07

Allocation concealment

Adequate

8

223

-0.24 (-0.47, -0.01)

0.04

24; 0.02

Unclear or nonadequate

19

344

-0.35 (-0.54, -0.16)

0.0002

28; 0.04

Blinding of assessor

Yes

12

306

-0.20 (-0.36,-0.03)

0.02

0; 0

No or unclear

15

261

-0.41 (-0.66,-0.16)

0.001

38;0.08

ITT analysis

Yes

13

315

-0.22 (-0.39, -0.06)

0.009

0; 0

No

14

252

-0.39 (-0.62, -0.16)

0.001

36; 0

Adequacy of outcomes for meta-analysis

Yes (means)

24

517

-0.35 (-0.51,-0.19)

<0.0001

28;0.04

No (medians)

3

43

-0.05 {-0.43,-0.32)

0.78

0; 0

Sample size

<25

3

30

-0.33 (-1.00,0.33)

0.33

34; 0.12

25 to 50

15

188

-0.41 (-0.70,-0.13)

0.005

46;0.11

>50

9

349

-0.23 (-0.39,-0.08)

0.004

0; 0

Patients with mental disorders included

Yes

16

312

-0.43 (-0.78, -0.08)

0.02

73; 0.28

No or unclear

14

315

-0.40 (-0.61, -0.19)

0.0002

38; 0.05


ITT, intention to treat. aStandardised mean difference (95% confidence interval).

Häuser et al. Arthritis Research & Therapy 2010 12:R79   doi:10.1186/ar3002

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