Table 3

Association of rs1805010 and rs1801275 with radiographic erosions after stratification by the presence of HLA-DRB1 SE and autoantibodies in African Americans with RA

Variable

Univariate analysis

Multivariate analysis




Erosiona n (%)

No erosion n (%)

Crude OR (95% CI)

P

Adjustedc OR (95% CI)

P


rs1805010, n (%)

n = 65b†

n = 74b

AA

15 (23.1)

15 (20.3)

0.89 (0.34 to 2.36)

0.82

0.95 (0.32 to 2.86)

0.93

AG

31 (47.7)

42 (56.8)

0.66 (0.30 to 1.47)

0.31

0.81 (0.33 to 1.99)

0.65

GG

19 (29.2)

17 (22.9)

1.00

--

1.00

--

rs1801275, n (%)

n = 65b

n = 75b

AA

3 (4.6)

9 (12.0)

0.31 (0.08 to 1.26)

0.10

0.30 (0.06 to 1.47)

0.14

AG

28 (43.1)

34 (45.3)

0.78 (0.39 to 1.55)

0.47

0.64 (0.30 to 1.40)

0.27

GG

34 (52.3)

32 (42.7)

1.00

--

1.00

--


aErosion score >0 at enrollment; bPatients with HLA-DRB1 SE, plus either anti-CCP or RF positive; c Adjusted by age at RA onset (continuous) + Gender + Disease duration (≥2 years versus <2 years) + rheumatoid nodules + smoking (ever versus never) + methotrexate (ever versus never).

Burgos et al. Arthritis Research & Therapy 2010 12:R75   doi:10.1186/ar2994

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