Table 2

Association of rs1805010 and rs1801275 with rheumatoid nodules after stratification by the presence of HLA-DRB1 SE and autoantibodies in African Americans with RA

Variable

Univariate analysis

Multivariate analysis




Rheumatoid nodules n (%)

No rheumatoid nodules n (%)

Crude OR (95% CI)

P

Adjustedb OR (95% CI)

P


rs1805010, n (%)

n = 51a

n = 171a

AA

17 (33.3)

31 (18.1)

1.61 (0.69 to 3.75)

0.27

2.74 (0.80 to 9.41)

0.11

AG

20 (39.2)

99 (57.9)

0.59 (0.27 to 1.28)

0.18

0.64 (0.21 to 1.96)

0.43

GG

14 (27.5)

41 (24.0)

1.00

--

1.00

rs1801275, n (%)

n = 51a

n = 172a

AA

7 (13.7)

14 (8.1)

2.44 (0.86 to 6.95)

0.09

8.08 (1.60 to 40.89)

0.01

AG

27 (52.9)

75 (43.6)

1.76 (0.89 to 3.48)

0.11

2.97 (1.08 to 8.17)

0.04

GG

17 (33.3)

83 (48.3)

1.00

--

1.00

--


aPatients with HLA-DRB1 SE plus either anti-CCP or RF positive. bAdjusted by age at RA onset (continuous) + Erosion + Gender + Disease duration (≥2 years versus <2 years) + smoking (ever vs. never) + methotrexate (ever versus never).

Burgos et al. Arthritis Research & Therapy 2010 12:R75   doi:10.1186/ar2994

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