Table 2 |
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|
Association of rs1805010 and rs1801275 with rheumatoid nodules after stratification by the presence of HLA-DRB1 SE and autoantibodies in African Americans with RA |
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|
Variable |
Univariate analysis |
Multivariate analysis |
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|
|
|
|
||||
|
Rheumatoid nodules n (%) |
No rheumatoid nodules n (%) |
Crude OR (95% CI) |
P |
Adjustedb OR (95% CI) |
P |
|
|
|
||||||
|
rs1805010, n (%) |
n = 51a |
n = 171a |
||||
|
AA |
17 (33.3) |
31 (18.1) |
1.61 (0.69 to 3.75) |
0.27 |
2.74 (0.80 to 9.41) |
0.11 |
|
AG |
20 (39.2) |
99 (57.9) |
0.59 (0.27 to 1.28) |
0.18 |
0.64 (0.21 to 1.96) |
0.43 |
|
GG |
14 (27.5) |
41 (24.0) |
1.00 |
-- |
1.00 |
|
|
rs1801275, n (%) |
n = 51a |
n = 172a |
||||
|
AA |
7 (13.7) |
14 (8.1) |
2.44 (0.86 to 6.95) |
0.09 |
8.08 (1.60 to 40.89) |
0.01 |
|
AG |
27 (52.9) |
75 (43.6) |
1.76 (0.89 to 3.48) |
0.11 |
2.97 (1.08 to 8.17) |
0.04 |
|
GG |
17 (33.3) |
83 (48.3) |
1.00 |
-- |
1.00 |
-- |
|
|
||||||
|
aPatients with HLA-DRB1 SE plus either anti-CCP or RF positive. bAdjusted by age at RA onset (continuous) + Erosion + Gender + Disease duration (≥2 years versus <2 years) + smoking (ever vs. never) + methotrexate (ever versus never). |
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|
Burgos et al. Arthritis Research & Therapy 2010 12:R75 doi:10.1186/ar2994 |
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