Table 8

Independent correlates of systolic blood pressure in women only, determined by using multivariate linear regression (GEE)

Variable

Parameter estimate

95% CI

P value


Age (years)

0.44

0.40, 0.48

< 0.0001

SLEDAI-2K scorea

0.37

0.30, 0.44

< 0.0001

Antimalarialsb

-1.32

-1.96, -0.69

< 0.0001

Immunosuppressivesc

-1.81

-2.48, -1.13

< 0.0001

Antihypertensivesd

6.85

6.17, 7.53

< 0.0001

Diabetese

2.43

1.16, 3.70

0.0002

Smokingf

1.12

0.20, 2.04

0.017

Hypercholesterolemiag

3.10

2.41, 3.78

< 0.0001

Lipid-lowering meds (statins)

-1.62

-2.52, -0.73

0.0004


GEE, generalized estimating equations; CI, confidence interval.

All variables were measured coincident with measurement of total cholesterol.

aSLE Disease Activity Index 2000; scores range from 0 to 105, with higher scores indicating more-active disease.

bAntimalarials include chloroquine and hydroxychloroquine.

cImmunosuppressives include methotrexate, azathioprine, mycophenolate mofetil,

cyclosporine, and cyclophosphamide.

dAntihypertensives include all classes of drugs used to lower blood pressure.

eDiabetes is defined as fasting plasma glucose > 7.0 mmol/L or diabetes therapy.

fSmoking one or more cigarettes per day.

gHypercholesterolemia defined as total plasma cholesterol > 5.2 mmol/L.

Nikpour et al. Arthritis Research & Therapy 2010 12:R125   doi:10.1186/ar3063

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