Table 3 |
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|
Bone parameters at the radius, tibia, and third metacarpal bone in RA patients and controls (means ± sd), P-values of two-sided Mann-Whitney tests (significant values are in bold), and difference between mean values of RA and control group |
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|
Group |
RA (n = 50) |
Ref (n = 100) |
Mann-Whitney test P-value |
Relative difference [%] |
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|
Bone |
Site |
Parameter |
Mean |
SD |
Mean |
SD |
||
|
|
||||||||
|
Radius |
4% |
BMC (g/cm) |
1.03 |
0.23 |
1.09 |
0.17 |
0.087 |
-5.5 |
|
Total CSA (mm2) |
339.3 |
55.3 |
338.4 |
48.2 |
0.599 |
0.3 |
||
|
Total BMD (mg/cm3) |
305.3 |
58.2 |
325.5 |
53.1 |
0.076 |
-6.2 |
||
|
Trab. BMD (mg/cm3) |
151.6 |
47.3 |
186.1 |
38.4 |
0.000 |
-18.5 |
||
|
66% |
BMC (g/cm) |
0.89 |
0.21 |
0.98 |
0.16 |
0.009 |
-9.2 |
|
|
Total CSA (mm2) |
139.4 |
26.1 |
132.6 |
20.7 |
0.110 |
5.1 |
||
|
Cort. CSA (mm2) |
63.3 |
19.6 |
71.8 |
13.3 |
0.017 |
-11.8 |
||
|
Cort. BMD (mg/cm3) |
1,094.0 |
78.7 |
1137.6 |
57.3 |
0.000 |
-3.8 |
||
|
Cort. Thickness (mm) |
1.80 |
0.59 |
2.14 |
0.45 |
0.001 |
-15.9 |
||
|
Tibia |
4% |
BMC (g/cm) |
2.76 |
0.60 |
3.02 |
0.43 |
0.002 |
-8.6 |
|
Total CSA (mm2) |
1,087.6 |
161.2 |
1071.7 |
126.9 |
0.251 |
1.5 |
||
|
Total BMD (mg/cm3) |
255.0 |
47.7 |
284.6 |
43.7 |
0.000 |
-10.4 |
||
|
Trab. BMD (mg/cm3) |
192.5 |
43.5 |
222.9 |
37.3 |
0.000 |
-13.6 |
||
|
66% |
BMC (g/cm) |
3.54 |
0.54 |
3.72 |
0.43 |
0.085 |
-4.8 |
|
|
Total CSA (mm2) |
549.9 |
81.4 |
548.3 |
67.6 |
0.956 |
0.3 |
||
|
Cort. CSA [mm2) |
266.4 |
43.9 |
282.6 |
33.4 |
0.048 |
-5.7 |
||
|
Cort. BMD (mg/cm3) |
1,117.0 |
54.8 |
1130.6 |
36.6 |
0.152 |
-1.2 |
||
|
Cort. Thickness (mm) |
3.78 |
0.65 |
4.05 |
0.52 |
0.029 |
-6.7 |
||
|
MCP3 |
4% |
BMC (mg/mm) |
40.48 |
9.96 |
43.70 |
7.18 |
0.031 |
-7.4 |
|
Total CSA (mm2) |
124.8 |
19.6 |
124.2 |
13.0 |
0.751 |
0.5 |
||
|
Total BMD (mg/cm3) |
321.6 |
66.0 |
351.8 |
44.4 |
0.001 |
-8.6 |
||
|
Trab. BMD (mg/cm3) |
266.0 |
80.5 |
303.2 |
44.9 |
0.001 |
-12.3 |
||
|
30% |
BMC (mg/mm) |
43.68 |
11.34 |
47.07 |
6.16 |
0.130 |
-7.2 |
|
|
Total CSA (mm2) |
76.10 |
13.60 |
71.26 |
11.52 |
0.015 |
6.8 |
||
|
Cort. CSA (mm2) |
31.59 |
8.49 |
34.66 |
4.22 |
0.088 |
-8.9 |
||
|
Cort. BMD (mg/cm3) |
1,100.1 |
87.5 |
1146.2 |
57.7 |
0.005 |
-4.0 |
||
|
Cort. Thickness (mm) |
1.19 |
0.36 |
1.38 |
0.23 |
0.005 |
-13.8 |
||
|
50% |
BMC (mg/mm) |
44.97 |
11.39 |
48.25 |
6.22 |
0.102 |
-6.8 |
|
|
Total CSA (mm2) |
59.69 |
8.15 |
56.66 |
6.13 |
0.019 |
5.3 |
||
|
Cort. CSA (mm2) |
33.04 |
8.56 |
36.06 |
4.70 |
0.043 |
- 8.4 |
||
|
Cort. BMD (mg/cm3) |
1,153.0 |
76.5 |
1,189.9 |
44.7 |
0.008 |
-3.1 |
||
|
Cort. Thickness (mm) |
1.48 |
0.45 |
1.71 |
0.28 |
0.001 |
-13.5 |
||
|
relative cortical area |
0.56 |
0.14 |
0.64 |
0.08 |
0.001 |
-12.5 |
||
|
|
||||||||
|
P-values are rounded to three decimal places, values of 0.000 are equivalent to P < 0.0005. BMC stands for bone mineral content per mm of slice thickness, CSA for cross-sectional area, BMD for volumetric bone mineral density, trab for trabecular and cort for cortical. |
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|
Aeberli et al. Arthritis Research & Therapy 2010 12:R119 doi:10.1186/ar3056 |
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