Table 3

Bone parameters at the radius, tibia, and third metacarpal bone in RA patients and controls (means ± sd), P-values of two-sided Mann-Whitney tests (significant values are in bold), and difference between mean values of RA and control group

Group

RA (n = 50)

Ref (n = 100)

Mann-Whitney test P-value

Relative difference [%]

Bone

Site

Parameter

Mean

SD

Mean

SD


Radius

4%

BMC (g/cm)

1.03

0.23

1.09

0.17

0.087

-5.5

Total CSA (mm2)

339.3

55.3

338.4

48.2

0.599

0.3

Total BMD (mg/cm3)

305.3

58.2

325.5

53.1

0.076

-6.2

Trab. BMD (mg/cm3)

151.6

47.3

186.1

38.4

0.000

-18.5

66%

BMC (g/cm)

0.89

0.21

0.98

0.16

0.009

-9.2

Total CSA (mm2)

139.4

26.1

132.6

20.7

0.110

5.1

Cort. CSA (mm2)

63.3

19.6

71.8

13.3

0.017

-11.8

Cort. BMD (mg/cm3)

1,094.0

78.7

1137.6

57.3

0.000

-3.8

Cort. Thickness (mm)

1.80

0.59

2.14

0.45

0.001

-15.9

Tibia

4%

BMC (g/cm)

2.76

0.60

3.02

0.43

0.002

-8.6

Total CSA (mm2)

1,087.6

161.2

1071.7

126.9

0.251

1.5

Total BMD (mg/cm3)

255.0

47.7

284.6

43.7

0.000

-10.4

Trab. BMD (mg/cm3)

192.5

43.5

222.9

37.3

0.000

-13.6

66%

BMC (g/cm)

3.54

0.54

3.72

0.43

0.085

-4.8

Total CSA (mm2)

549.9

81.4

548.3

67.6

0.956

0.3

Cort. CSA [mm2)

266.4

43.9

282.6

33.4

0.048

-5.7

Cort. BMD (mg/cm3)

1,117.0

54.8

1130.6

36.6

0.152

-1.2

Cort. Thickness (mm)

3.78

0.65

4.05

0.52

0.029

-6.7

MCP3

4%

BMC (mg/mm)

40.48

9.96

43.70

7.18

0.031

-7.4

Total CSA (mm2)

124.8

19.6

124.2

13.0

0.751

0.5

Total BMD (mg/cm3)

321.6

66.0

351.8

44.4

0.001

-8.6

Trab. BMD (mg/cm3)

266.0

80.5

303.2

44.9

0.001

-12.3

30%

BMC (mg/mm)

43.68

11.34

47.07

6.16

0.130

-7.2

Total CSA (mm2)

76.10

13.60

71.26

11.52

0.015

6.8

Cort. CSA (mm2)

31.59

8.49

34.66

4.22

0.088

-8.9

Cort. BMD (mg/cm3)

1,100.1

87.5

1146.2

57.7

0.005

-4.0

Cort. Thickness (mm)

1.19

0.36

1.38

0.23

0.005

-13.8

50%

BMC (mg/mm)

44.97

11.39

48.25

6.22

0.102

-6.8

Total CSA (mm2)

59.69

8.15

56.66

6.13

0.019

5.3

Cort. CSA (mm2)

33.04

8.56

36.06

4.70

0.043

- 8.4

Cort. BMD (mg/cm3)

1,153.0

76.5

1,189.9

44.7

0.008

-3.1

Cort. Thickness (mm)

1.48

0.45

1.71

0.28

0.001

-13.5

relative cortical area

0.56

0.14

0.64

0.08

0.001

-12.5


P-values are rounded to three decimal places, values of 0.000 are equivalent to P < 0.0005. BMC stands for bone mineral content per mm of slice thickness, CSA for cross-sectional area, BMD for volumetric bone mineral density, trab for trabecular and cort for cortical.

Aeberli et al. Arthritis Research & Therapy 2010 12:R119   doi:10.1186/ar3056

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