Table 5

Interaction between PADI4 haplotypes and SE alleles in susceptibility to erosive and non-erosive RA *

Controls, No

All RA cases

Erosive RA

Non-erosive RA

Subgroup

No.

OR (95% CI)

No.

OR (95% CI)

No.

OR (95% CI)

GTG and SE carriage

1,003

1,311

1,070

241

GTG-negative/SE-negative

245

109

1

89

1

20

1

GTG-negative/SE-positive

133

257

5.17 (3.57 to 7.48)

210

5.05 (3.41 to 7.47)

47

5.70 (3.04 to 10.67)

GTG-positive/SE-negative

399

320

1.89 (1.37 to 2.61)

257

1.80 (1.27 to 2.54)

63

2.11 (1.19 to 3.75)

GTG-positive/SE-positive†

226

625

7.46 (5.38 to 10.36)

514

7.52 (5.31 to 10.65)

111

7.73 (4.39 to 13.61)

Diplotype and SE carriage

1,003

1,311

1,070

241

ACC/ACC/SE-negative

245

109

1

89

1

20

1

ACC/GTG/SE-negative

290

217

1.72 (1.22 to 2.42)

177

1.65 (1.14 to 2.38)

40

1.85 (1.01 to 3.41)

GTG/GTG/SE-negative

109

103

2.39 (1.56 to 3.66)

80

2.22 (1.41 to 3.50)

23

2.87 (1.40 to 5.86)

ACC/ACC/SE-positive

133

257

5.19 (3.58 to 7.51)

210

5.07 (3.42 to 7.51)

47

5.71 (3.05 to 10.70)

ACC/GTG/SE-positive

179

428

6.23 (4.42 to 8.77)

357

6.29 (4.37 to 9.03)

71

6.16 (3.41 to 11.11

GTG/GTG/SE-positive‡

47

197

12.74 (8.03 to 20.23)

157

12.98 (7.97 to 21.14)

40

14.47 (7.11 to 29.45)

* OR and 95% CI were adjusted for age, sex, and smoking. Erosive RA cases were classified as Steinbrocker scores II-IV. RA, rheumatoid arthritis; OR, odds ratios; CI, confidence intervals.

† The attributable proportion (95% CI) due to interaction was 0.19 (-0.06 to 0.43) in erosive RA and 0.11 (-0.27 to 0.48) in non-erosive RA.

‡ The attributable proportion (95% CI) due to interaction was 0.48 (0.25 to 0.72) in erosive RA and 0.46 (0.14 to 0.78) in non-erosive RA.

Bang et al. Arthritis Research & Therapy 2010 12:R115   doi:10.1186/ar3051