Table 4

Interaction between PADI4 haplotypes and SE alleles in susceptibility to anti-CCP-positive and -negative RA*

Controls, No

All RA cases

anti-CCP-positive RA

anti-CCP-negative RA




Subgroup

No.

OR (95% CI)

No.

OR (95% CI)

No.

OR (95% CI)


GTG and SE carriage

1,003

1,311

820

145

GTG-negative/SE-negative

245

109

1

50

1

18

1

GTG-negative/SE-positive

133

257

5.17 (3.57 to 7.48)

168

8.20 (5.23 to 12.85)

21

2.40 (1.18 to 4.89)

GTG-positive/SE-negative

399

320

1.89 (1.37 to 2.61)

176

2.32 (1.54 to 3.49)

53

1.80 (0.99 to 3.25)¶

GTG-positive/SE-positive†

226

625

7.46 (5.38 to 10.36)

426

11.63 (7.73 to 17.51)

53

4.10 (2.23 to 7.53)

Diplotype and SE carriage

1,003

1,311

820

145

ACC/ACC/SE-negative

245

109

1

50

1

18

1

ACC/GTG/SE-negative

290

217

1.72 (1.22 to 2.42)

122

2.14 (1.39 to 3.30)

33

1.52 (0.81 to 2.88)¶

GTG/GTG/SE-negative

109

103

2.39 (1.56 to 3.66)

54

2.85 (1.68 to 4.85)

20

2.58 (1.24 to 5.37)

ACC/ACC/SE-positive

133

257

5.19 (3.58 to 7.51)

168

8.24 (5.25 to 12.92)

21

2.41 (1.18 to 4.92)

ACC/GTG/SE-positive

179

428

6.23 (4.42 to 8.77)

298

9.87 (6.47 to 15.06)

31

2.90 (1.50 to 5.60)

GTG/GTG/SE-positive‡

47

197

12.74 (8.03 to 20.23)

128

19.45 (11.32 to 33.42)

22

9.59 (4.39 to 20.98)


* OR and 95% CI were adjusted for age, sex, and smoking. RA, rheumatoid arthritis; anti-CCP, anti-cyclic citrullinated peptide autoantibody; OR, odds ratios; CI, confidence intervals.

† The attributable proportion (95% CI) due to interaction was 0.16 (-0.10 to 0.42) in anti-CCP-positive RA and 0.19 (-0.26 to 0.63) in anti-CCP-negative RA.

‡ The attributable proportion (95% CI) due to interaction was 0.45 (0.20 to 0.71) in anti-CCP-positive RA and 0.61 (0.29 to 0.92) in anti-CCP-negative RA.

¶Association was not significant (P = 0.05 and P = 0.20, respectively).

Bang et al. Arthritis Research & Therapy 2010 12:R115   doi:10.1186/ar3051

Open Data