Table 3

Association of PADI4 haplotypes, HLA-DRB1 SE alleles and smoking with susceptibility to erosive and non-erosive RA*

Controls, No

All RA cases

Erosive RA

Non-erosive RA

Subgroup

No.

OR (95% CI)

No.

OR (95% CI)

No.

OR (95% CI)

GTG-negative†

378

366

1

299

1

67

1

GTG-positive

625

945

1.64 (1.31 to 2.05)

771

1.62 (1.29 to 2.05)

174

1.62 (1.14 to 2.31)

SE-negative

644

429

1

346

1

83

1

SE-positive

359

882

4.31 (3.49 to 5.32)

724

4.45 (3.55 to 5.57)

158

4.16 (2.97 to 5.83)

Non-smoking

856

1,089

1

904

1

185

1

Smoking

134

197

2.28 (1.47 to 3.52)

146

2.01 (1.25 to 3.25)

51

3.83 (2.02 to 7.27)

* Values are the number of subjects. OR and 95% CI for GTG carriage versus non-carriage were adjusted for age, sex, SE alleles and smoking. OR and 95% CI for SE carriage versus non-carriage were adjusted for age, sex, GTG carriage and smoking. OR and 95% CI for smoking versus non-smoking were adjusted for age, sex, GTG carriage and SE alleles. Erosive RA cases were classified as Steinbrocker scores II-IV. RA, rheumatoid arthritis; anti-CCP, anti-cyclic citrullinated peptide autoantibody; OR, odds ratios; CI, confidence intervals.

† Three subjects (two RA patients and one control) who carried ACC and a rare haplotype were excluded from the analysis and hence the GTG-negative subjects carried only ACC/ACC.

Bang et al. Arthritis Research & Therapy 2010 12:R115   doi:10.1186/ar3051