Immunohistochemistry of human neutrophil peptides 1-3 (HNP1-3) and human β-defensin 2 (HBD 2) in the synovial lining and sublining area of an RA patient (similar in OA patients). Antibodies to HNP1-3 stained positive in the lining and adjacent sublining area, whereas HBD-2 was found only in deep sublining zones. Magnification 400×.
Riepl et al. Arthritis Research & Therapy 2010 12:R110 doi:10.1186/ar3044