Open Access Highly Accessed Research article

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis

Fiona E McCann*, Andrew C Palfreeman, Melanie Andrews, Dany P Perocheau, Julia J Inglis, Peter Schafer, Marc Feldmann, Richard O Williams and Fionula M Brennan

Arthritis Research & Therapy 2010, 12:R107  doi:10.1186/ar3041

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