Disease incidence, clinical score, and paw thickness readouts of treated and untreated CAIA mic. (a) Disease incidence in control and treated collagen antibody-induced arthritis (CAIA) mice (n = 12 mice per group), defined as any animal showing a clinical score ≥1 in at least one paw. (b) Average clinical score values of all paws for control and treated CAIA mice (n = 12 mice per group). (c) Average changes in paw thickness from day 4 to day 8 for control and treated CAIA mice. Study is representative of three separate experiments. #P < 0.05, ***P < 0.0001.
Peterson et al. Arthritis Research & Therapy 2010 12:R105 doi:10.1186/ar3038