No role for ERβ in modulation of rat AA. Male lewis rats were injected with complete freund's adjuvant containing mycobacterium tuberculosis. Daily treatment (subcutaneous) with dexamethasone (1 mg/kg), ethinyl estradiol (EE at 2.5 mg/kg), ERB-79 (3 mg/kg) or vehicle (0.5% gelatin- 5% mannitol) started when the first signs of arthritis were observed (day 10). Animals (n = 8 per group) were scored daily for arthritis. Statistical analysis was performed using analysis of variance followed by post hoc Least Significant Difference (LSD)test (*** P ≤ 0.001). AUC, area under the curve. ER, estrogen receptor.
Dulos et al. Arthritis Research & Therapy 2010 12:R101 doi:10.1186/ar3032