Table 1

Proliferation of chondrocytes isolated and cultured at 280 mOsm, 380 mOsm and 480 mOsm

Chondrocyte proliferation (%)


Culture condition

Passage 0

Passage 1

Passage 2

Passage 3


280 mOsm

100 (68 ± 28 hours)

100 (89 ± 54 hours)

100 (67 ± 48 hours)

100 (57 ± 11 hours)

380 mOsm

113 ± 18

89 ± 25

99 ± 9

154 ± 41

480 mOsm

675 ± 405*

180 ± 24*

168 ± 28*

165 ± 81*


Data presented as relative doubling times in percentage of cells cultured at 280 mOsm, mean ± standard deviation. The absolute doubling time ± standard deviation in hours is displayed in brackets. n = 6. mOsm, milliosmoles per kilogram of water. *P < 0.05.

van der Windt et al. Arthritis Research & Therapy 2010 12:R100   doi:10.1186/ar3031

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