Table 1

Nitric oxide-induced T cell functions in sysemic lupus erythematosus and rheumatoid arthritis

Altered T cell function

SLE

RA


Mitochondrial hyperpolarization and biogenesis

Higher [10]

Normal [27]

Tlymphocyte NO production

Normal [10]

Increased [27]

TCR-induced rapid and sustained Ca2+ signal

Rapid-increased, sustained-decreased [10]

Normal [22]

TCR expression

Decreased [34]

Decreased [61]

mTOR activity

Increased [29]

Not known

ATP level

Decreased [28]

Normal [28]

Monocyte NO production

Increased [10]

Increased [46]


mTOR, mammalian target of rapamycin; NO, nitric oxide; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; TCR, T cell antigen receptor.

Nagy et al. Arthritis Research & Therapy 2010 12:210   doi:10.1186/ar3045