Figure 7.

Adoptive cell transfer of Bcl-xL- and FoxP3-transduced regulatory T cells reduces paw inflammation. The protocol of adoptive cell transfer for collagen-induced arthritis is described in the legend of Figure 5. On day 60 of immunization, hind foot paws were amputated, fixed, and decalcified. The tissues were embedded in paraffin, sectioned, and stained. (a) Hematoxylin and eosin (HE) staining. (b) HE semiquantitative score. (c) Safranin O-fast green staining. (d) Safranin O-fast green semiquantitative score. Data are representative of two similar experiments (*P <0.05, Student unpaired t test).