Open Access Research article

B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin

Stacey R Dillon1*, Brandon Harder1, Kenneth B Lewis1, Margaret D Moore1, Hong Liu1, Thomas R Bukowski1, Nels B Hamacher1, Megan M Lantry1, Mark Maurer1, Cecile M Krejsa1, Jeff L Ellsworth1, Susan Pederson1, Keith B Elkon2, Mark H Wener2, Maria Dall'Era3 and Jane A Gross1

Author Affiliations

1 Preclinical Research and Development, ZymoGenetics, Inc., 1201 Eastlake Ave East, Seattle, WA 98102, USA

2 Division of Rheumatology, School of Medicine, University of Washington, 1959 NE Pacific Street, Box 356428, Seattle, WA 98195-6428, USA

3 Division of Rheumatology, Department of Medicine, University of California, San Francisco, 533 Parnassus Avenue, Box 0633, San Francisco, CA 94143-0633, USA

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Arthritis Research & Therapy 2010, 12:R48  doi:10.1186/ar2959


See related editorial by Stehl, http://arthritis-research.com/content/12/2/111

Published: 19 March 2010

Additional files

Additional file 1:

Supplemental methods. Additional methodologic details.

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Additional file 2:

Supplemental tables. Supplemental Tables 1 and 2 show serum heterotrimer levels and disease-activity markers in a subset of samples from patients with SLE.

Format: PDF Size: 71KB Download file

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